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Endocrine Abstracts (2017) 50 S1.3 | DOI: 10.1530/endoabs.50.S1.3

SFEBES2017 Symposia Steroids and the Skeleton (3 abstracts)

Skeletal actions of glucocorticoids – in vivo models

Claire Wood 1,


1Roslin Institute, Edinburgh, UK; 2Institute of Genetic Medicine,
Newcastle, UK.


Glucocorticoids are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, important and a well characterized pre-clinical model is vital for the evaluation of new interventions.

Currently, there is no established animal model to investigate GC effects on skeletal development and there are pros and cons to consider with the different protocols used to induce osteoporosis and growth retardation. This talk will summarize the literature that is available and highlight the models and techniques employed in experimental studies to date.

Volume 50

Society for Endocrinology BES 2017

Harrogate, UK
06 Nov 2017 - 08 Nov 2017

Society for Endocrinology 

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