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Endocrine Abstracts (2018) 56 S24.1 | DOI: 10.1530/endoabs.56.S24.1

France.


A current challenge in physiology/pathology is translating cell-transduction processes identified in vitro into the living organism, especially where cell-cell interaction and dynamics have key functional roles. The pituitary gland, regulating a diverse range of essential physiological functions, exemplifies this challenge: stimulation from the brain is relayed as variable hormone pulses (the hypothalamic-pituitary (HP) system), which are decoded by peripheral organs into differential effects. The stimulatory inputs and intermediary/final secretory output of the HP system have impressive differences in time-scale and the number of cells involved: a few thousand hypothalamic neurons with signalling frequencies in the millisecond range drive hundreds of thousands of pituitary cells to secrete hormone pulses over a period of hours. These features of the HP system are conserved across a diverse range of mammals. However, how pituitary networks transform hypothalamic inputs into hormone pulses in vivo was unknown. Using newly-developed techniques for imaging and manipulating cells in vivo, namely in freely-behaving mouse models, we unveiled how the pituitary somatotroph network translates its hypothalamic inputs into GH pulses in the bloodstream.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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