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Endocrine Abstracts (2019) 63 S20.3 | DOI: 10.1530/endoabs.63.S20.3

ECE2019 Symposia News on nutrition: when to eat what (3 abstracts)

PREDIMED Plus trial - energy-restricted Mediterranean diet plus exercise and metabolic health

Emilio Ros


Spain.


The PREDIMED trial showed that long-term adherence to an ad libitum Mediterranean diet (MeDiet) supplemented with extra-virgin olive oil (EVOO) or mixed nuts reduced incident cardiovascular disease (CVD) in older subjects at high risk. No clinical trials have been conducted to demonstrate whether weight loss sustained over time with an energy-restricted healthy diet plus increased physical activity (PA) reduces CVD risk. We designed the PREDIMED-PLUS study, a 6-year, multicentre, randomized clinical trial for the primary prevention of CVD with an energy-restricted MeDiet plus behavioural support and advice to increase PA, aimed at losing weight in comparison with a control, energy-unrestricted MeDiet without counsel on PA (www.isrctn.com/ISRCTN89898870). Participants are 6874 older individuals (aged 55–75 y) with overweight/obesity and the metabolic syndrome and they receive gifts of EVOO and nuts to promote the MeDiet irrespective of group assignment. The final goal regarding adiposity is to obtain a between-group average absolute difference in weight loss and waist circumference reduction >5%. The results of the pilot study concerning the first 610 randomized participants completing intervention for 12 months showed that diet and PA changes were in the expected direction, with significant improvements in the intervention group compared with the control group. After 12 months, participants in the intervention group lost an average of 3.2 kg vs. 0.7 kg in the control group (P<0.001). Weight loss ≥5% occurred in 33.7% of participants in the intervention group vs. 11.9% in the control group (P<0.001). Compared to participants in the control group, those in the intervention group had greater improvements in classical cardiovascular risk factors, except for blood pressure and LDL-cholesterol levels, and greater reductions in insulin resistance, hemoglobin A1c, and circulating levels of leptin, IL-18 and MCP-1 (P<0.05, all). In conclusion, among overweight/obese adults with metabolic syndrome, an intervention using energy-restricted MeDiet, PA and behavioral support for 12 months resulted in clinically meaningful weight loss and improvements in intermediate cardiovascular risk factors.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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