Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2003) 6 P48

SFE2003 Poster Presentations Growth and development (6 abstracts)

QLS-H, A MEASURE OF QUALITY OF LIFE IN ADULT UK GHD PATIENTS

S Patel 1 , RJM Ross 2 & D Edwards 1


1Eli Lilly and Company Limited, Lilly House, Priestley Road, Basingstoke, Hants, UK RG24 9NL; 2University of Sheffield, Sheffield, UK.


QLS-H is a new, weighted QoL questionnaire developed for patients with hypopituitarism. We evaluated QLS-H data from UK patients in the HypoCCs International surveillance study, and compared results with a sample of the general UK population (n=1090).

The QLS-H questionnaire was administered at baseline and at yearly intervals. Scores were corrected for age and gender differences, and expressed as Z-scores based on UK-specific reference ranges. Using this method, a score of 0 is normal, and a negative Z-score indicates below normal QoL. QLS-H data from the UK patient database in HypOCCs was analysed at baseline (n=266) and after 1-year therapy (n=238).

Over 38% of patients at baseline had QLS-H Z-scores of less than minus2.0. Patients with the poorest QoL scores were those patients in the middle age bands ranging from 25 to 55y, in contrast to patients <25y, who had higher Z-scores. 82% of patients showed improvement in their QoL score, with over 29% of patients improving with a change in Z-score of greater than +2.0 and 50% of patients improving with a change in Z-score of greater than +1.0. This indicates a substantial improvement in quality of life scores toward the normal range following GH treatment.

In conclusion, UK hypopituitary patients showed a marked improvement in QoL following one years GH therapy. The individually weighted QoL tool, QLS-H, which is able to correct for age and gender effects and compare results to the general population, is a useful QoL tool for assessment of adult GHD patients.

Volume 6

194th Meeting of the Society for Endocrinology and Society for Endocrinology joint with Diabetes UK Endocrinology and Diabetes Day

Society for Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.

My recently viewed abstracts