ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2005) 9 S23 
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Oxidative stress and cardiovascular disease

AF Dominiczaks

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An increasing body of evidence suggests that oxidative stress is involved in the pathogenesis of a wide range of cardiovascular diseases including hypertension, type 2 diabetes, hypercholesterolaemia, atherosclerosis and heart failure. It is a matter for debate whether this increased oxidative stress has a primary causative role in cardiovascular disease pathogenesis or rather is a vascular sequel of disease progression. There is, however, emerging evidence for genetic components from genome-wide gene expression studies and from systematic evaluation of candidate genes within the oxidative stress pathways. In both cases it can be concluded that the restoration of vascular reactive oxygen species to normal is an important but frequently neglected therapeutic target.

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