Is there any relationship between the BsmI and FokI polymorphisms in the vitamin d receptor gene and bone mineral density in men?
J Kuliczkowskaaksej, A Trzmiel, A Filus, U Tworowska, D Jedrzejuk & A Milewicz
Introduction: Results of many studies indicate that the BsmI and FokI polymorphisms in the VDR gene may influence bone tissue metabolism and may be useful in means of identifying patients at greater risk of osteoporosis.
Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI and FokI) and its relationship to phenotypic features characterizing bone status (BMD).
Materials and methods: 176 randomly selected men, aged 2565 years (mean 54.16) were studied. VDR gene genotypes were determined using PCR-RFLP method. BMD was measured using DXA method. The study protocol was approved by the local Ethical Committee.
Results: Genotype bb was found in 28.7%, BB in 11.4%, and bB in 59.9%. Genotype ff was found in 9.3%, FF in 30.6%, and fF in 60.1%. There was no significant differences regarding BMD between any of genotypes.
Conclusions: These data suggest that the VDR genotypes do not seem to be useful for identifying patients at greater risk of osteoporosis, however it awaits to be confirmed by a population-based study.