The patients with HIV lipodystrophy syndrome have lower total fat mass but similar free fat mass

European Congress of Endocrinology 2006

Glasgow, UK
01 April 2006 - 05 April 2006
European Society of Endocrinology
British Endocrine Societies

Endocrine Abstracts (2006) 11 P211

P Freitas¹, D Carvalho¹, F Correia¹, T Faria², B Perez², R Marques³, R Serrão³, J Pereira², A Mota Miranda³ & JL Medina¹

¹Endocrinology Department, Hospital S. João, Porto, Portugal; ²Nuclear Medicine, Hospital S. João, Porto, Portugal; ³Infectious Disease Department, Hospital S. João, Porto, Portugal; ⁴University of Porto Medical School, Porto, Portugal.

Introduction: The highly active antiretroviral therapy (HAART) completely changed the natural history and body composition of the infected patients. The lipodystrophy syndrome of HIV-infected patients (IP) is characterized by fat mass redistribution in the limbs, face lipoatrophy and abdominal lipohypertrophy. Dual-energy x-ray absorptiometry scan (DEXA) and bioelectrical impedance (BIA) are techniques to determine body composition (BC).

Aims: Evaluate the BC in HIV-IP treated with HAART with (CL) and without clinical lipodystrophy (WCL).

Patients and methods: We studied 117 HIV-IP, 25 women and 92 men, by anthropometry, BIA (Tanita) and DEXA.

	CL (n=82)	WCL (n=35)	P
Age (years)	48.8±10.9	40.4±10.1	<0.001
Duration of disease (years)	8.6±4.1	6.5±3.3	<0.05
Duration of treatment HAART (years)	7.7±4.0	4.8±3.2	<0.005
BMI (Kg/m²)	24.4±3.8	25.9±4.9	<0.05
Waist circumference (WC) (cm)	90.2±10.2	92.6±13.2	ns
Hip circumference (HC) (cm)	91.9±7.1	99.0±8.4	<0.001
Thigh circumference (TC) (cm)	46.3±4.8	50.4±5.8	<0.001
Total Fat Mass (TFM) (%) (BIA) (n=117)	18.8±7.6	24.3±10.7	<0.05
Total Fat Mass (TFM) (%) (DEXA) (n=83)	15.2±8.9	27.2±10.8	<0.001
Fat Free Mass (FFM) (Kg) (BIA) (n=117)	53.3±7.4	53.4±8.6	ns
Fat Free Mass (FFM) (Kg) (DEXA) (n=83)	51.2±7.2	50.6±9.3	ns
Total Body Water (Kg) (BIA) (n=117)	39.0±5.4	39.1±6.3	ns
To compare the variables we used Mann-Whitney test.

Results: The patients with CL had similar WC to WCL but lower HC and TC. In patients with CL we observed a % TFM significantly lower (BIA and DEXA) but similar FFM and TBW.

Conclusions: The patients with HIV-Lipodystrophy Syndrome had WC, FFM and TBW similar to the patients WCL. The TFM of the same patients is significantly reduced.

Endocrine Abstracts (2006) 11 P211