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Endocrine Abstracts (2006) 11 P416

ECE2006 Poster Presentations Diabetes, metabolism and cardiovascular (174 abstracts)

Severity of depression in patients with type 1 and type 2 diabetes and its relation to the level of glycemia control and anti-depressive therapy

LR Tsutskiridze , RB Kurashvili , GR Kurashvili , MG Khelashvili , MA Nishnianidze , EL Shelestova & MG Dundua


Georgian Diabetes Center, Tbilisi, Georgia.


Background and Aims: There are consistent findings about increased prevalence of depressive disorders in diabetes. The aim of the study was to reveal prevalence of depression in patients (pts) with type 1 (DM1) and type 2 (DM2) diabetes.

Materials and Methods: Totally, 157 pts with DM were questioned. To assess depression degree Beck’s scale was used, and 83 depressive pts (scores >10), were allocated into 2 groups (Gr.): Gr.1 (n=44)–DM2 pts (m20/f24), mean age 57.5±8.4 yrs, diabetes duration 6±2 yrs, HbA1c–8.8±1.3%, Gr. 2 (n=39)–DM1 pts (m16/f23), mean age 30±5 yrs, diabetes duration–7±2 yrs, HbA1c–9.2±1.9%. Assessment scores: Gr.1(m) >55 (7 pts/35%), 30–50 (8 pts/40%), ≥10 (5 pts/25%); (f) >60 (11 pts/45.8%), 30–50 (8 pts/33.4%), >15 (5 pts/20.8%). Gr.2(m) >50 (8 pts/50%), 30–50 (7pts/43.7%), ≥10 (1pts/6.25%); (f) >60 (12/52.2%), 30–50 (8/34.8%), >20 (3/13%). 18 Gr.1 pts were treated with insulins and oral hypoglycemic agents (OHAs); 26–only with OHAs. Intensive insulin therapy was used in 22 Gr.1 pts. Tianeptin 3 tablets/daily was used for depression treatment in both groups.

Results: Repeated examination at month 3 post study initiation showed: HbA1c dropped by 7.3±0.9%; P=0.000 (Gr.1), and by 6.5±0.6%; P=0.000 (Gr.2). Beck’s scores were: Gr.1 (m): 30–40 (7 pts), 20–30 (8 pts), 0 (5 pts); (f): 50–60 (11 pts), 20–30 (8 pts), ≥10 (5 pts). Gr.2 (m): 30-40 (8 pts), ≥20 (7 pts), 0 (1 pts); (f): 50–60 (12 pts), 20–25 (8 pts), ≧8 (3 pts). At entry there was no statistically evident difference in depression severity between the groups (P=0.177; P=0.537, respectively). Post treatment there was statistically evident correlation between decline in HbA1c levels and depression severity in both groups, this evidence was relevant for males and females: Gr.1(m) r=0.948, P=0.000; (f) r=0.909, P=0.000. Gr.2(m) r=0.915, P=0.000; (f) r=0.921, P=0.000.

Conclusion: We conclude: 1.There was no statistically evident difference in depression severity between the DM types. 2.There is statistically evident post-treatment correlation between glycemia control level and depression degree in both groups.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

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