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Endocrine Abstracts (2006) 11 P424

ECE2006 Poster Presentations Diabetes, metabolism and cardiovascular (174 abstracts)

Left ventricular geometry and contractile ability in type 2 diabetes and non-diabetic patients with mild hypertension

N Beridze , I Bochorishvili , M Iashvili , R Kurashvili & M Dundua


Medical Diagnostic Center, Tbilisi, Georgia.


The aim: To reveal relation between altered left ventricular (LV) geometry (G) and contractile ability (CA) in nonbese type 2 diabetic (DM2) patients with mild hypertension (MH).

Materials and methods: BP at rest, 24-h ambulatory BP monitoring and echocardiography were investigated in 70 non-obese males, aged 25–50 yrs. They were divided into the following groups: Gr.1, n=15 – DM2 and normal BP, fasting C-peptide (C-p, ng/ml) 4.3±0.95, HbA1c 10.5±0.75%; Gr.2, n=10 – DM2 and latent hypertension, ≤190/110 mmHg, fasting C-p 4.2±0.75, HbA1c 11.2±0.95%; Gr.3, n=15 – DM2 with overt MH ≤190/110 mmHg, fasting C-p 3.95±1.1, HbA1c 10.7±0.83. Gr.4, n=10 – nonDM pts with latent hypertension, C-p 2.1.±0.54, HbA1c 4.5±1.1; Gr.5, n=10 – nonDM pts with MH, fasting C-p 1.95±0.62, HbA1c 5.2±0.95%; Controls (CG), n=10 – healthy persons. Thyroid pathology was excluded in all cases. Using LVMI and RWT, LVG was divided into: normal (N) – LVMI<51 g/ht2, RWT<0.44; concentric remodeling (CR) – LVMI<51 g/ht2, RWT>0.44; eccentric LV hypertrophy (EH-LLVMI>51 g/ht2, RWT<0.44), concentric LV hypertrophy- (CH) (LVMI>51 g/ht2, RWT>0.44).

Results: Gr.1 shows EH with EDV 127.0±2.1 ml, EF 63.9±2.5%, FS 34.3±0.9%, that did not differ from CG, (P>0.05) Gr.2 and 3 pts. In addition EH shows tendency to worsening of diastolic (EDV =199.5±3.8 ml, 220.0±4.5 ml respectively, P<0.01) and systolic functions (FS 28.0±0.9%), EF 53.3 P<0.05). Gr.4 pts had CR accompanied with significant (as compared to CG, P<0.01) increase in EDV 210.0±2.4 ml, but preserved systolic function EF 65.0±2.6%, FS 35.0±0.9%. Gr.5 revealed CH with elevated EDV up to 230±3.2 ml and insignificant (P>0.5) changes in systolic function (EF 61.3±2.5%; FS 32.0±0.9%)

Conclusion: Thus, EH characteristics of insulin resistance syndrome in DM2 pts make favorable background for disturbing heart diastolic and systolic functions in presence of even moderate hypertension.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

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