Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2006) 11 P837

ECE2006 Poster Presentations Thyroid (174 abstracts)

The role of autoimmunity and thyroid function on pregnancy outcomes in euthyroid women with autoimmune disease undergoing assisted reproduction

R Negro 1 , G Formoso 1 , L Coppola 2 , G Presicce 2 , T Mangieri 2 , A Pezzarossa 3 & D Dazzi 3


1Dept. of Endocrinology, Lecce, Italy; 2Dept. of Physiopathology of Human Reproduction, Brindisi, Italy; 3Dept. of Internal Medicine, Fidenza, Italy.


Context: Euthyroid women positive for thyroid antibodies are prone to develop subclinical/overt hypothyroidism during gestation and seem to suffer from a poor outcome.

Objective: Assessing if patients with autoimmune thyroid disease undergoing Assisted Reproduction Technologies (ART) are afflicted by poor pregnancy and/or delivery rate and if the outcome is conditioned by pre-ART thyroid status.

Design: Prospective study since January 1999 until June 2006. Women undergoing ART were screened for TSH, FT4, TPOAb.

Setting: Division of Physiopathology of Human Reproduction.

Patients: A total of 464 euthyroid women were selected; 52 (11.2%) were TPOAb (+).

Main outcomes: The endpoints were pregnancy rate, miscarriage rate and obstetrical complications.

Results: No difference in pregnancy rate was observed between women with and without antibodies. The rates of miscarriage and pre-term delivery were higher in TPOAb (+) than TPOAb (−) [P=0.049; RR=1.1 (95% CI=0.98–1.25); P=0.023; RR=1.2 (95% CI=0.98–1.4), respectively]. In TPOAb (+), women who miscarried displayed higher TSH values before ART (2.8 mIU/L) compared to the ones who delivered or failed to become pregnant (1.6 and 1.7 mIU/L; P=0.032 and P=0.018 respectively).

Conclusions: In euthyroid women undergoing ART the pregnancy rate is not affected either by the presence of TPOAb or thyroid function. TPOAb (+) showed significantly increased number of miscarriages and pre-term deliveries; thyroid function before ART appears to play a pivotal role in determining the gestation outcome. These results show that thyroid autoimmunity and even a mild thyroid impairment represent risk factors for obstetrical complications (miscarriage and pre-term delivery). Further studies are required to ascertain possible benefits of levothyroxine in such patients.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

Browse other volumes

Article tools

My recent searches

No recent searches.