Endocrine Abstracts (2007) 14 P443

Hyperthyroidism in molar pregnancy: rapid preoperative preparation by plasmapheresis and complete after evacuation

Adil Dogan Azezli1, Taner Bayraktaroglu1, Samet Topuz2, Sevgi Kalayoglu Besisik3 & Yusuf Orhan1


1Istanbul University, Istanbul Faculty of Medicine, Endocrinology and Metabolism, Istanbul, Capa/Fatih, Turkey; 2Istanbul University, Istanbul Faculty of Medicine, Obstetrics and Gynaecology, Istanbul, Capa/Fatih, Turkey; 3Istanbul University, Istanbul Faculty of Medicine, Haematology, Istanbul, Capa/Fatih, Turkey.


Human chorionic gonadotropin bears structural homology to pituitary thyrotropin. The extremely elevated levels of human chorionic gonadotropin in patients with molar pregnancy or other trophoblastic diseases can lead to hyperthyroidism. We describe a patient with molar pregnancy who had secondary hyperthyroidism prepared rapidly by plasmapheresis for surgery. After first plasmapheresis the clinical picture improved dramatically. Three subsequent plasmapheresis provided a 75.1% decrease in serum free T3 concentrations and 63.9% free T4 concentrations and recovered after evacuation. This is the first using of the plasmapheresis in rapidly preparation of the patient who had secondary hyperthyroidism due to molar pregnancy.

Article tools

My recent searches

No recent searches.