Endocrine Abstracts (2007) 14 P459

Prostate specific antigen (PSA) in women with menstrual disturbances and mastopathy

Stanislaw Radowicki & Michal Kunicki

Departement of Gynaecological Endocrinology, Medical University, &rr;Warsaw, Poland.

The aim of the study was to assess free and total prostate-specific antigen-PSA in serum of women with menstrual ditubances and mastopathy.

Material and methods: We examined 176 patients who were admitted to the Departement of Gynaecological Endocrinology with benign breasts pathology. According to clinical examination and sonographical findings women were didvided into two groups:

• group I: 114 with fibrocystic breast disease. Sonographical findings revealed the presence of cysts<10 mm in diameter.

• group II: 62 women with fibrocystic breast disease, cysts>10 mm in diameter.

The control group – 46 healthy women aged 18–45 years with regular menses and no pathological finding in ultrasonography examination

The menstrual patterns were definied according to presented classification:

• Eumenorrhoea- cycle lengh 21 to 35 days., Polymenorrhoea- cycle <25 days

• Oligomenorrhoea- cycle>32 days, Amenorrhoea secundaria - absence of menstruation for>180 days.

One-way analysis of variance ANOVA was performed and Mann-Whitney test when apopriate. P<.05 was considered statistically significant.

The mean free and total PSA concentrations in relation to menstrual disturbances in women with mastopathy. Presented as x±SD; *=differ significantly (P<0.05)

Menstrual patternFree PSA concetration(ng/ml)
Total PSA concentration
Group IGroup IIControl
Am. Secundaria1.07±1.51Undetectable*

Conclusions: 1. The mean free and total-PSA concentrations did not differ significantly between healthy women and women with mastopathy and regular menstruation

2. Women with cysts<10 mm (group I) and oligomenorrhoea or amenorrhoea secundaria had significantly higher free PSA concentrations than women with cysts>10 mm

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