Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2007) 14 P459 

Prostate specific antigen (PSA) in women with menstrual disturbances and mastopathy

Stanislaw Radowicki & Michal Kunicki

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The aim of the study was to assess free and total prostate-specific antigen-PSA in serum of women with menstrual ditubances and mastopathy.

Material and methods: We examined 176 patients who were admitted to the Departement of Gynaecological Endocrinology with benign breasts pathology. According to clinical examination and sonographical findings women were didvided into two groups:

• group I: 114 with fibrocystic breast disease. Sonographical findings revealed the presence of cysts<10 mm in diameter.

• group II: 62 women with fibrocystic breast disease, cysts>10 mm in diameter.

The control group – 46 healthy women aged 18–45 years with regular menses and no pathological finding in ultrasonography examination

The menstrual patterns were definied according to presented classification:

• Eumenorrhoea- cycle lengh 21 to 35 days., Polymenorrhoea- cycle <25 days

• Oligomenorrhoea- cycle>32 days, Amenorrhoea secundaria - absence of menstruation for>180 days.

One-way analysis of variance ANOVA was performed and Mann-Whitney test when apopriate. P<.05 was considered statistically significant.

The mean free and total PSA concentrations in relation to menstrual disturbances in women with mastopathy. Presented as x±SD; *=differ significantly (P<0.05)

Menstrual patternFree PSA concetration(ng/ml)
Total PSA concentration
Group IGroup IIControl
Am. Secundaria1.07±1.51Undetectable*

Conclusions: 1. The mean free and total-PSA concentrations did not differ significantly between healthy women and women with mastopathy and regular menstruation

2. Women with cysts<10 mm (group I) and oligomenorrhoea or amenorrhoea secundaria had significantly higher free PSA concentrations than women with cysts>10 mm

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