Prostate specific antigen (PSA) in women with menstrual disturbances and mastopathy
Stanislaw Radowicki & Michal Kunicki
The aim of the study was to assess free and total prostate-specific antigen-PSA in serum of women with menstrual ditubances and mastopathy.
Material and methods: We examined 176 patients who were admitted to the Departement of Gynaecological Endocrinology with benign breasts pathology. According to clinical examination and sonographical findings women were didvided into two groups:
group I: 114 with fibrocystic breast disease. Sonographical findings revealed the presence of cysts<10 mm in diameter.
group II: 62 women with fibrocystic breast disease, cysts>10 mm in diameter.
The control group 46 healthy women aged 1845 years with regular menses and no pathological finding in ultrasonography examination
The menstrual patterns were definied according to presented classification:
Eumenorrhoea- cycle lengh 21 to 35 days., Polymenorrhoea- cycle <25 days
Oligomenorrhoea- cycle>32 days, Amenorrhoea secundaria - absence of menstruation for>180 days.
One-way analysis of variance ANOVA was performed and Mann-Whitney test when apopriate. P<.05 was considered statistically significant.
The mean free and total PSA concentrations in relation to menstrual disturbances in women with mastopathy. Presented as x±SD; *=differ significantly (P<0.05)
|Menstrual pattern||Free PSA concetration(ng/ml)|
| ||Total PSA concentration|
| ||Group I||Group II||Control|
| ||0.48±1.23||0.09±0.18|| |
| ||0.95±2.75||0.97±2.14|| |
| ||3.25±4.60||0.02±0.03|| |
Conclusions: 1. The mean free and total-PSA concentrations did not differ significantly between healthy women and women with mastopathy and regular menstruation
2. Women with cysts<10 mm (group I) and oligomenorrhoea or amenorrhoea secundaria had significantly higher free PSA concentrations than women with cysts>10 mm