ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2007) 14 P467 
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Multiple endocrine dependent tumours in a dog patient without measurable endocrine consequences

Julianna Thuroczy1, Aniko Tibold1 & Lajos Balogh2

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Testicular neoplasmas are 5–15 percent of total tumours number in male dogs. Seminomas are the most common type of testicular tumours in dog.

The thyroid tumours are large, unilateral palpable masses in neck region in most of the cases. Although seventy percent of malignant thyroid neoplasmas are carcinomas, 5–20% of them are endocrinologically active which induce the clinical signs of hyperthyroidism.

Seven – twenty one percent of skin tumours are mastocytomas in dog but the incidence of them is higher in spayed female and intact male dogs, which should indicate the testosterone dependency.

Eight years old argentin dog was present at our clinic with clinical signs of alopecia, weight loss and ointment faeces. Plasma biochemical parameters were in reference ranges. The total thyroxin concentration was 30.11 nmol/l which is fit to euthyroid state. An altered density focus in right testis was visualized by the ultrasonographic examination. Neither testosterone nor estrogen serum concentrations were high. The Tc-pertechnetate uptake of left thyroid gland was increased in opposite the visualisation of right thyroid gland was decreased. The left thyroid gland, both testes and a 1 cm diameter nodule in skin were surgically removed.

Seminoma in both testes, follicular compact cell carcinoma and C-cell carcinoma in removed thyroid gland and Grade-II type mastocytoma in skin were histologically established.

The faeces got the normal consistency following the operation. The hair grows finished in sixth week after the operation. The thyroxin concentration after transient decrease reached the 35.48 nmol/l level in four month. Plasma TSH concentration was 0.272 ng/ml.

The combination of three different endocrine tumours with a suspected hormone dependent tumour suggests the relation of their development. I spite of hormone dependent tumours the plasma hormone levels were ambiguous and reached to diagnosis with use of complex diagnostic imaging techniques.

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