Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

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Published by BioScientifica
Endocrine Abstracts (2007) 14 P479 

Pituitary insufficiency after traumatic brain injury in southwest Hungary

Orsolya Nemes, Zsuzsanna Nagy, Beata Bodis, Laszlo Bajnok, Dora Szellar, Endre Czeiter, Andras Buki, Tamas Doczi & Emese Mezosi

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Traumatic brain injury (TBI) often results in long-term pituitary insufficiency. Regular endocrine screening of TBI patients is advised after the acute phase of the treatment period. We monitored pituitary functions in 32 TBI patients (28 men, 4 women). Endocrine tests were performed from 3 to 36 months after the brain injury. Thyroid functions, cortisol and ACTH levels, prolactin, sex hormone concentrations, GH/IGF1 axis and posterior pituitary function were evaluated. Additional stimulatory tests were done if data indicated pituitary hypofunction: insulin/arginine/glucagone/TRH tests. Mean age of the patients was 35.1 years (men: 35, women: 36). Endocrine abnormalities developed in 37.5% of the patients, 75% of these in one axis and 25% in two axes. Three patients had hyperprolactinemia. Normal endocrine functions were detected in 62.5% of TBI patients. GH deficiency was the most frequently found abnormality in TBI patients (9 cases-28.1%), central hypogonadism was diagnosed in 4 patients (12.5%), and central hypadrenia in 2 (6.25%). Central hypothyroidism and diabetes insipidus were not present in our studied patient group. In conclusion, approximately one third of monitored TBI patients had pituitary dysfunction during follow-up. The majority of these cases displayed single axis disturbance, with GH deficiency representing the leading abnormality. Systematic endocrine follow-up of TBI patients should be extended in Hungary.

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