Aim of this study was to evaluate lipid profile and the severity of GHD, in a large group of TBI patients with or without GH deficiency. We assayed lipid profile (Total-, HDL- Cholesterol, Triglycerides) in 62 TBI subjects 12 months after TBI (41 M, 21 F, 1381 yrs, BMI: 24.6±0.6 kg/m2), and in 62 sex-, age- and BMI-matched controls. Based on the GH peak after GHRH+ARG test, patients were stratified as: 1) severe GHD (GH peak ≤ 9 μg/l; n=13; 20.9%); 2) partial GHD (GH peak in between 9.116.5 μg/l; n=6; 9.7%); 3) non-GHD (GH peak >16.5 μg/l; n=43; 69.3%). IGF-I levels were lower (P<0.001) in patients with severe GHD (88.7±11.1 μg/L) than in those with partial GHD, non-GHD and in controls (148.1±33.9, 219.2±10.7, and 251.8±10.8 μg/L, respectively). HDL-cholesterol were lower (P<0.01) in patients with severe GHD (44.1±2.7 mg/dL) than in those non-GHD and in controls (54.4±1.3 and 59.3±1.1, respectively), while, no significant differences was found in partial GHD. In patients with severe GHD, total- and HDL-cholesterol ratio (4.9±0.4, P<0.01) were higher than in those with partial GHD (4.4±0.2,), non-GHD (3.9±0.2), and controls (2.9±0.1). In addition, partial GHD patients had total- and HDL-cholesterol ratio (4.4±0.2, P<0.01) higher than those non-GHD (3.9±0.2), and controls (2.9±0.1). Triglycerides levels were not different among severe GHD, partial GHD and non GHD TBI patients and controls. In all subjects, a significant correlation was found between the GH peak and age (r=−0.41; P<0.01), BMI (r=−0.33; P<0.05), IGF-I (r=0.36; P<0.01), total cholesterol (r=−0.37; P<0.05), HDL cholesterol (r=0.36; P<0.05), total- and HDL- cholesterol ratio (r=−0.47; P<0.01). IGF-I was correlated with age (r=−0.54, P<0.001), total cholesterol (r=−0.46; P<0.01), HDL cholesterol (r=0.39; P<0.05), total- and HDL- cholesterol ratio (r=−0.51; P<0.01). In conclusion, impairment of lipid profile was evident in TBI patients with severe GHD.
28 Apr - 02 May 2007
European Society of Endocrinology