Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2007) 14 P649 

Insulin levels and lipid profile in lean women with polycystic ovary syndrome

Mirjana Stojkovic, Milos Zarkovic, Jasmina Ciric, Biljana Beleslin, Slavica Savic, Djordje Marina, Bozo Trbojevic & Milka Drezgic

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Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Insulin resistance is one of the features of PCOS and potentially affect lipid metabolism.

Objectives: The aim of this study was to compare basal insulin levels and lipid profile in lean women with PCOS with weight matched healthy controls.

Methods: The study group consisted of 64 women divided in two subgroups (1. PCOS group, n=48; age 25.7±6.2; BMI 21.3±1.9 kg/m2. 2. group of healthy controls, n=16, age 26.8±6.4; BMI 20.3±1.6 kg/m2). Data were analyzed by the t test.

Results: Mean basal glucose levels were 4.38±0.46 mmol/L vs. 4.54±0.23 mmol/L, without statistically significant difference between groups. Mean basal insulin levels were significantly higher in PCOS group than in healthy controls (24.82±16.34 mIU/L vs. 6.47±3.19 mIU/L; P=0,001;). Cholesterol, HDL and LDL cholesterol levels did not reach statistically significant difference between groups, while triglyceride levels were significantly higher in PCOS group than in healthy controls (1.05±0.44 mmol/L vs. 0.73±0.22; P=0,009;).

Conclusions: These data suggest that PCOS per se, without obesity, affects insulin secretion and lipid metabolism, mainly in triglyceride levels which enhances atherogenic potential in this subjects.

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