Insulin levels and lipid profile in lean women with polycystic ovary syndrome
Mirjana Stojkovic, Milos Zarkovic, Jasmina Ciric, Biljana Beleslin, Slavica Savic, Djordje Marina, Bozo Trbojevic & Milka Drezgic
Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Insulin resistance is one of the features of PCOS and potentially affect lipid metabolism.
Objectives: The aim of this study was to compare basal insulin levels and lipid profile in lean women with PCOS with weight matched healthy controls.
Methods: The study group consisted of 64 women divided in two subgroups (1. PCOS group, n=48; age 25.7±6.2; BMI 21.3±1.9 kg/m2. 2. group of healthy controls, n=16, age 26.8±6.4; BMI 20.3±1.6 kg/m2). Data were analyzed by the t test.
Results: Mean basal glucose levels were 4.38±0.46 mmol/L vs. 4.54±0.23 mmol/L, without statistically significant difference between groups. Mean basal insulin levels were significantly higher in PCOS group than in healthy controls (24.82±16.34 mIU/L vs. 6.47±3.19 mIU/L; P=0,001;). Cholesterol, HDL and LDL cholesterol levels did not reach statistically significant difference between groups, while triglyceride levels were significantly higher in PCOS group than in healthy controls (1.05±0.44 mmol/L vs. 0.73±0.22; P=0,009;).
Conclusions: These data suggest that PCOS per se, without obesity, affects insulin secretion and lipid metabolism, mainly in triglyceride levels which enhances atherogenic potential in this subjects.