Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2007) 14 P77 

Dialysis therapy and its complications

Evgeniya Bublik1, Gagik Galstyan1, Galina Melnichenko1, Victor Safonov1, Euginy Shutov1, Pavel Filipcev1 & Oleg Udovichenko1

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Aim: To study prevalence of foot complications in patients on dialysis therapy and evaluate the role the haemodynamic changes during dialysis procedure in development of foot problems.

Methods: 109 dialysis patients, mean age 49 years. 60 of them had diabetes mellitus (DM): 29 on haemodialysis (HD), 31 on peritoneal dialysis (PD). Non-diabetic patients (NDM): 24 HD, 25 PD.

Vascular status: doppler, photoplethysmography. Polyneuropathy: NDS. Monitoring of BP: during and after dialysis (follow-up period 14 months).

Results: Peripheral vascular disease (PVD) was associated with DM (16 DM vs. 1 NDM). Polyneuropathy: 51 DM, and in 7 NDM.

Ulcers were diagnosed only in DM patients (prevalence 25%). The number of patients with diabetic ulcers was increased after starting dialysis therapy (from 4 to 12) and it was due to increasing neuroischemic ulcers (from 0 to 8, P=0,016).

Transient intra- and postdialysis hypotension (TH) was determined in 15 HD, 5 PD. This group had significant fall of pressure in toe arteries during TH. Neuroischemic ulcers were frequently diagnosed in the group with PVD and HD, than with PVD and without HD; P=0,001.

Conclusions: Diabetic patients on dialysis therapy have high risk of neuroischemic ulcers. TH can intensify PVD and provoke neuroischemic ulcers.

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