Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2008) 15 P277 

Diagnostic and therapeutic implications of using calculated free testosterone in men with low-normal total testosterone levels

Sudhanshu Chitale1, Krishna Sethia1 & Ketan Dhatariya2

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Materials and methods

Twenty-eight men with erectile dysfunction (ED) were investigated with TT, SHBG, albumin, fasting blood glucose, hormonal profile and a lipid profile. Free testosterone and bio-available testosterone (BAT) were calculated in all men using the calculator on the ISSAM website (

Results: The mean age was 55.57 years (range: 27–6 years±11.48), with a mean body mass index of 29.69 kg/m2 (range: 19.02–39.19±4.33). 28.5% had type 2 diabetes. Only 5/28 (17.8%) men had their TT assessed by their primary care physicians prior to referral to the secondary care service. 7/28 (25%) men were clearly hypogonadal based on TT. Of the remaining 21 men with TT in the normal range (9–27 nmol/l), 13 (61.9%) had TT <14 nmol/l (borderline TT) and 8 (38.1%) had more than 14 nmol/l. 10/13 (76.9%) men with borderline TT had low levels of cFT, and 3/13 had normal levels of cFT. All those with TT>14 nmol/l had normal cFT values. BAT was also lower than normal in 5/10 but within the reference range in 5/10 with low cFT. This is likely to be due to the normal levels of albumin and relatively low levels of SHBG.


Our study highlights the importance of calculating cFT in order to accurately diagnose biochemical hypogonadism in men presenting with clinical hypogonadism but low-normal levels of TT.

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