Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 17 P14

BSPED2008 Poster Presentations (1) (56 abstracts)

Growth and pubertal status following pubertal induction in boys with IBD

A Mason 1 , S Wong 1 , R Russell 2 , P McGrogan 2 & S Ahmed 1


1Department of Child Health, Royal Hospital for Sick Children Glasgow, Yorkhill, Glasgow, UK; 2Department of Paediatric Gastroenterology, Royal Hospital for Sick Children Glasgow, Yorkhill, Glasgow, UK.


Background: Children with inflammatory bowel disease (IBD) may suffer from growth and pubertal delay.

Objective: To assess pubertal status and growth in a group of boys with IBD before (T+0) and 6 months after (T+6) initiation of testosterone therapy.

Methods: Retrospective study of boys with IBD undergoing pubertal induction. Height (Ht) and pubertal status were obtained at T+0 and T+6. Markers of disease activity and data on concomitant medication were also collected. Response to testosterone was based on advance of pubertal status and a greater than 50% increase in height velocity (HV).

Results: Eight boys with IBD (7 with Crohn’s disease and 1 with Ulcerative colitis) and median age of 14.8 years (range, 13.6, 15.6), median TS of 1 (1, 2) and a median bone age delay of 2.9 years (0.8, 3.5) had pubertal induction using either Sustanon 50 mg i.m. monthly or Andropatch 2.5 mg or 5 mg daily applied for 12 h each day. Seven boys showed an advance of pubertal status to a median TS of 3 (2, 4) and 6 boys had a greater than 50% increase in HV following Testosterone. Median HV at T+0 and T+6 was 1.6 and 6.9 cm/year, respectively (P=0.005). Median Ht SDS at T−6, T+0 and T+6 was −1.4(−3.0, −0.8), −1.6 (−3.4, −1.1) and −1.4 (−3.3, −1.1), respectively. Median HV SDS at T+0 and T+6 was −4.2 (−7.6, +2) and +1.2 (−2.7, +8.5) respectively. HV SDS was significantly different following treatment when corrected for both age and pubertal stage (P=0.005 and P=0.01). Median albumin, CRP, ESR and platelets were similar at T+0 and T+6. Although median CRP showed a significant correlation with HV at T+6 (r=−0.786; P=0.021), there were no clear associations of growth response to concomitant therapy.

Conclusion: In this group of boys with IBD Testosterone therapy improves growth and pubertal status to a variable extent and needs further systematic study.

Volume 17

36th meeting of the British Society for Paediatric Endocrinology and Diabetes

British Society for Paediatric Endocrinology and Diabetes 

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