Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2010) 22 P18

ECE2010 Poster Presentations Adrenal (66 abstracts)

The aldosterone renin ratio based on the plasma renin activity and the direct renin assay for diagnosing aldosterone-producing adenoma

GianPaolo Rossi 1 , Marlena Barisa 1 , GiovanBattista Desideri 2 , Claudio Letizia 3 , Mauro Maccario 4 , Alberto Morganti 5 , Gaetana Palumbo 6 , Anna Patalano 7 , Anna Realdi 1 , Elisabetta Roman 1 , Teresa Maria Seccia 1 & Achille Cesare Pessina 1


1DMCS, Internal Medicine 4, University of Padova, Padova, Italy; 2Internal Medicine and Public Health, University of L’Aquila, L’Aquila, Italy; 3Internal Medicine, University of Rome, Rome, Italy; 4Endocrinology, University of Turin, Turin, Italy; 5Internal Medicine, University of Milan, Milan, Italy; 6Internal Medicine, Legnano, Italy; 7Endocrinology, University of Padova, Padova, Italy.


The screening for primary aldosteronism (PA) is based on the aldosterone/renin ratio (ARR), which is calculated with the plasma renin activity (PRA) as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains uncertain.

Aim of the study was to head-to-head compare the ARR based on PRA (ARR-P) to on DRA (ARR-D), at baseline and post-captopril, for identifying aldosterone-producing adenoma (APA) in a subset (251 patients) of the PAPY Study.

The area (AUC) under the ROC curves was employed for estimating the accuracy of ARR-D and ARR-P for identifying APA and for between tests comparison. PA was found in 13.2% patients, 6.4% of whom had APA and 6.8% idiopathic hyperaldosteronism (IHA); 218 (86.8%) had primary hypertension. The PRA and the DRA showed a weaker correlation at baseline (r=0.26, P<0.0001) and a stronger post-captopril (r=0.65, <0.0001). Both the ARR-D and the ARR-P were useful for identifying APA, as shown by AUC under the ROC curves (0.870±0.058 and 0.973±0.028, respectively) >0.50 (both P<0.0001); at a between-test comparison the ARRs did not differ significantly. For the ARR-D the optimal cut-off value for identifying APA was 27.3, remarkably similar to that previously determined for the ARR-P. Thus, the ARR-D represents a reasonable alternative to the ARR-P for detecting APA.

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