Comparative evaluation of bone density measurement with DXA or quantitative ultrasound of bone in the diagnosis and treatment monitoring of osteoporosis a field study
Andreas Knauerhase1, Susanne Beier1, Christiana Zingler2, Gerritt Tolkemitt3 & Rainer Hampel1
Question: Can be reliably diagnosed osteoporosis with quantitative ultrasound of bone? Can the therapeutic progress of a specific osteoporosis therapy reliably judged by that?
Patients and methods: Three hundred and twenty patients were enrolled between July 1999 and October 2004. All patients were studied in the osteoporosis clinic at time 0, after 1, 2 and 3 years. BMD was done with Hologic QDR-1000 (low back or hip) and the Osteometer DTU one (parameters SOS and BUA, measured heel). We also recorded anamnestic and anthropometric parameters and laboratory values and treatment data. The statistical analysis covered in the normal arithmetic means and standard deviation, correlation coefficient, correlation analysis, the MannWhitney test and the Wilcoxon test.
Results: At time 0 quantitative ultrasound and DXA correlated significantly (P<0.001). Among the other times, the significances are inconsistent. This is true for the whole group and all subgroups.
Conclusion: The Osteosonometrie is suitable for the diagnosis of osteoporosis. Its importance in assessing the course of therapy is much lower.