Serum IGF1 levels correlate to improvement of functional independence after ischemic stroke
Daniel Aberg1, Katarina Jood2, Christian Blomstrand2, Christina Jern3, Claes Ladenvall3, Michael Nilsson2, Jorgen Isgaard1 & David Aberg1
Context and objective: GH and IGF1 both have neuroprotective and regenerative effects in experimental stroke. Our aim was to investigate whether the endogenous serum-IGF1 (s-IGF1) levels were correlated to recovery of functional independence in stroke patients.
Subjects and methods: The analysis of s-IGF1 was performed in 400 patients of both sexes, aged 1869 years old, and 40 controls previously included in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) study. Recovery after ischemic stroke was evaluated by the modified Rankin scale (mRS) and the Scandinavian stroke scale (SSS). Serum samples were collected at two occasions: subacutely (approximately 4 days) and 3 months after stroke.
Results: s-IGF1 increased and reached a plateau 35 days after stroke (P<0.05) and s-IGF1 were lower in the elderly patients. Subacute s-IGF1 and 3-month s-IGF1 were both correlated to improvement in mRS between 3 months and 2 years (P<0.01 and P<0.001 respectively).
Conclusions: A high s-IGF1 in the rehabilitation phase of stroke correlate to better recovery of functional independence.