Insulin resistance in smokers and non-smokers in young healthy population
Emel Acar1, Yusuf Aydin2, Elif Onder2, Hakan Cinemre1, Seher Kir1, Hulya Coskun1, Ozlem Kudas1 & Mehmet Turgut1,2
Introduction: Insulin resistance is the decrease sensitivity of tissues in the body to insulin effect. Obesity, advanced age, sedentary life and smoking are the factors leading to an increase in insulin resistance. In our study, we aimed to evaluate the relationship between the insulin resistance and smoking in individuals without advanced age, obesity, high blood glucose levels and hypertension.
Materials and methods: We included in this study 100 patients (50 non-smokers, 50 smokers) who admitted to internal medicine and endocrinology outpatient clinics of Duzce University School of Medicine, from February 2009 to July 2009. Patients waist/hip ratio, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, HDL cholesterol, fasting blood glucose, insulin, HbA1c were measured. HOMA values were calculated.
Results: Between both groups, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, fasting blood glucose, insulin, HbA1c and HOMA values were similar (P>0.05). HDL cholesterol levels in smokers compared to non-smokers was statistically significant (P<0.05). In stepwise multiple linear regression analysis, triglyceride and waist/hip ratio were identified as an important independent predictor of an increase in HOMA in smokers.
Conclusion: Our study has shown that there is no relationship between cigarette smoking and insulin resistance in young population. We are in thought of that the presence of cigarette smoking with conditions causes increase in insulin resistance such as the advanced age, obesity, genetic predisposition, sedentary life and abnormal blood glucose levels can contribute to an increase in insulin resistance.