In spite of achievements in diabetology on insulinotherapy optimization, the number of patients with T1DM, who do not achieve target indicators of compensation, remains to be high.
Objective: To estimate compensation and frequency of self-control carrying out among patients with T1DM in Belarus.
Materials and methods: Total 965 patients with T1DM (467m, 498f), mean age (M±m) 34.33±0.51 years (1.8072.75), age of T1D manifestation 22.17±0.43 years special form including questions about T1DM. HbA1c (%) was measured by biochemical analyzer ARCHITECT c8000 (Abbott).
Results: The level of HbA1c>7.5% in all age groups. Among patients aged 4059, HbA1c is higher among females (8.74±0.13) than among males (8.35±0.16; P<0.01). The greatest proportion comprised patients with HbA1c level >9%, that was found in 31% of people above 60 years, in 71% of adolescents; and patients with HbA1c level of 88.9% that was found in 13% of adolescents, 23% of people above 60. Forty-two percent of patients (females above 40 years old) were found to have overweight (BMI>25 kg/m2). Frequency of self-control (29.58±1.55 per month) and actual hypoglycemias (5.96±0.31 per month) is higher among females (P<0.001). Maximal frequency of self-control were revealed among children aged 19 (among boys 75.29±18.49, among girls 82.04±10.92) and minimal frequency among patient above 60 years old (among males 6.6±4.09, among females 7.9±1.85; P<0.01). Hypoglycemia frequency was found to be maximal in girls aged 19 (6.63±1.19) and minimal in males aged 4059 (3.87±0.45; P<0.001).
Conclusion: Basic proportion (62.07%) of patients with T1DM have negative compensation that is associated with high risk of late complications (HbA1c>8%). Low level of compensation is the result of self-control low frequency and hypoglycemia high frequency, especially among children and adolescents, and is accompanied by high frequency of overweight among females over 40 years old.
Prague, Czech Republic
24 - 28 Apr 2010
European Society of Endocrinology