Endocrine Abstracts (2010) 22 P303

Metabolic control in patients with type 1 diabetes mellitus in Belarus

Maryia Rusalenko1 & Tatiana Mokhort2

1The Republic Research Center for Radiation Medicine and Human Ecology, Gomel, Belarus; 2Belarussian State Medical University, Minsk, Belarus.

In spite of achievements in diabetology on insulinotherapy optimization, the number of patients with T1DM, who do not achieve target indicators of compensation, remains to be high.

Objective: To estimate compensation and frequency of self-control carrying out among patients with T1DM in Belarus.

Materials and methods: Total 965 patients with T1DM (467m, 498f), mean age (M±m) 34.33±0.51 years (1.80–72.75), age of T1D manifestation 22.17±0.43 years special form including questions about T1DM. HbA1c (%) was measured by biochemical analyzer ‘ARCHITECT c8000’ (Abbott).

Results: The level of HbA1c>7.5% in all age groups. Among patients aged 40–59, HbA1c is higher among females (8.74±0.13) than among males (8.35±0.16; P<0.01). The greatest proportion comprised patients with HbA1c level >9%, that was found in 31% of people above 60 years, in 71% of adolescents; and patients with HbA1c level of 8–8.9% that was found in 13% of adolescents, 23% of people above 60. Forty-two percent of patients (females above 40 years old) were found to have overweight (BMI>25 kg/m2). Frequency of self-control (29.58±1.55 per month) and actual hypoglycemias (5.96±0.31 per month) is higher among females (P<0.001). Maximal frequency of self-control were revealed among children aged 1–9 (among boys 75.29±18.49, among girls 82.04±10.92) and minimal frequency – among patient above 60 years old (among males 6.6±4.09, among females 7.9±1.85; P<0.01). Hypoglycemia frequency was found to be maximal in girls aged 1–9 (6.63±1.19) and minimal in males aged 40–59 (3.87±0.45; P<0.001).

Conclusion: Basic proportion (62.07%) of patients with T1DM have negative compensation that is associated with high risk of late complications (HbA1c>8%). Low level of compensation is the result of self-control low frequency and hypoglycemia high frequency, especially among children and adolescents, and is accompanied by high frequency of overweight among females over 40 years old.

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