Endocrine Abstracts (2010) 22 P309

Metabolic syndrome in patients with type 2 diabetes mellitus in Surabaya, Indonesia

Olivia Handayani & Hans Tandra

Diabetes, Obesity, Metabolism, Endocrine (DOME) Clinic, Surabaya, East Java, Indonesia.

Objective: To determine the frequency of metabolic syndrome (MS) in adult patients with type 2 diabetics (T2D) in Surabaya, Indonesia based on NCEP-ATP III.

Methods: This is a retrospective study. All consecutive adults with T2D were evaluated for the presence or absence of MS. According NCEP-ATP III, metabolic syndrome (MS-ATP III) was defined as two of four of the following: central obesity (waist circumference >102 cm in males and >88 cm in females), hypertriglyceridemia (150 mg/dl or specific treatment), low HDL cholesterol (<40 mg/dl in males, <50 mg/dl in females or specific treatment) and hypertension (SBP 130 mmHg or DBP 85 mmHg or specific treatment).

Results: We analyzed 150 medical charts. The mean age was 58.7±11.2 years and had been living with diabetes for more than 7±2.9 years. Fifty-two percent of patients had a family history of T2D and 128 (85.3%) was correlated with MS definition. Most of the MS patients were females (72.7%) and middle-aged (mean 57.9±10.5 years). Of 81.2% among them were treated with oral hypoglycemic agents (OHAs), 13.1% with the combination of insulin and OHAs, and only 6.7% were on insulin therapy alone. Only (37.4%) of the subjects met the glycemic target of HbA1c≤6.5%. Whereas in 22 non MS diabetic patients (17.7%), HbA1c<6.5% were found in 71.2%.

Conclusion: The diagnosis of MS is frequent in adult patients with T2D, mostly correlated with female sex and middle-aged. Metabolic syndrome was significantly related to poorly regulation of blood glucose in type 2 diabetic patients.

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