Study objective: To determine risk factors of hypoglycemic episodes among patients with type 1 diabetes mellitus (T1D) using the continuous glucose monitoring system (CGMS).
Materials and methods: Total 120 female patients with T1D were examined. The 1st group was with concealed hypoglycemic episodes (n=79) that has made 66% and the 2nd group was with frank hypoglycemic episodes (n=41) that has made 31% of the total number of the examined. The groups are compared by average age (29.14±7.33 years), T1D duration (10.00±7.33), HbA1c, % (9.28±2.07).
Results: The risk factors of hypoglycemic episodes are as follows: the age of 18 till 30 years (latent hypoglycemia cases OR=1.18; 95% CI 1.061.30; P=0.002, manifestative hypoglycemic cases OR=1.21; 95% CI 1.071.38; P=0.004), HbA1c above 7% (latent hypoglycemia cases OR=0.71; 95% CI 0.590.85; P<0,001, manifestative hypoglycemic cases OR=0.74; 95% CI 0.580.94; P=0.014), level of average glucose of intercellular fluid below 13 mmol/l (latent hypoglycemic cases OR=0.74; 95% CI 0.620.89; P=0.001, manifestative hypoglycemic cases OR=0.77; 95% CI 0.640.93; P=0.007).
Conclusions: Latent hypoglycemic episodes dominated among the registered hypoglycemic reactions. The risk factors of hypoglycemic episodes are as follows: young age, HbA1c above 7%, level of average glucose of intercellular fluid below 13 mmol/l.
Prague, Czech Republic
24 - 28 Apr 2010
European Society of Endocrinology