ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2010) 22 P311 
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Risk estimation of hypoglycemic episodes among patients with type 1 diabetes mellitus

Elena Makhlina1,2 & Tatiana Mokhort1,2

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Study objective: To determine risk factors of hypoglycemic episodes among patients with type 1 diabetes mellitus (T1D) using the continuous glucose monitoring system (CGMS).

Materials and methods: Total 120 female patients with T1D were examined. The 1st group was with concealed hypoglycemic episodes (n=79) that has made 66% and the 2nd group was with frank hypoglycemic episodes (n=41) that has made 31% of the total number of the examined. The groups are compared by average age (29.14±7.33 years), T1D duration (10.00±7.33), HbA1c, % (9.28±2.07).

Results: The risk factors of hypoglycemic episodes are as follows: the age of 18 till 30 years (latent hypoglycemia cases OR=1.18; 95% CI 1.06–1.30; P=0.002, manifestative hypoglycemic cases OR=1.21; 95% CI 1.07–1.38; P=0.004), HbA1c above 7% (latent hypoglycemia cases OR=0.71; 95% CI 0.59–0.85; P<0,001, manifestative hypoglycemic cases OR=0.74; 95% CI 0.58–0.94; P=0.014), level of average glucose of intercellular fluid below 13 mmol/l (latent hypoglycemic cases OR=0.74; 95% CI 0.62–0.89; P=0.001, manifestative hypoglycemic cases OR=0.77; 95% CI 0.64–0.93; P=0.007).

Conclusions: Latent hypoglycemic episodes dominated among the registered hypoglycemic reactions. The risk factors of hypoglycemic episodes are as follows: young age, HbA1c above 7%, level of average glucose of intercellular fluid below 13 mmol/l.

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