Introduction: The EDIN study evaluated the clinical course of patients with type 2 diabetes mellitus (T2DM) from the start of the insulin treatment to a minimum of 5 years, within routine clinical practice in Spain.
Objective: To describe the characteristics of patients at onset of insulin treatment.
Methods: Observational study that consecutively included patients with T2DM, ≥30 years old and treated with insulin for at least 5 years. Data were collected retrospectively in 2008 from patients clinical records.
Results: Fifty-three sites participated in the study. A total of 405 patients were enrolled and 377 were included in the analysis (52.0% males; mean age (S.D.) 65 (9.1) years; mean body mass index (S.D.) 29.9 (4.7) kg/m2). Mean time from onset of T2DM (S.D.) was 8.8 (6.9) years. Almost two-thirds of the patients had family history of T2DM. Insulin treatment pattern showed that 48% of the patients were prescribed human basal insulin and 29.4% were treated with premix human insulin. Three hundred sixty patients (95.5%) were being treated with oral antidiabetic medications. Collection of cardiovascular risk factors showed that ≥50% of the patients presented overweight (75.1%), hypertension (50.4%) and dyslipidemia (59.2%); however, 60.2% of the patients were non-smokers. Microvascular complications were identified in 121 (32.1%) patients and the most frequent conditions were diabetic retinopathy (n=92, 76.0%), diabetic nephropathy (n=46, 38.0%) and diabetic neuropathy (n=41, 33.9%). Macrovascular complications were present in 66 patients (17.5%), among which coronary artery disease (n=38, 57.6%) and cardiovascular disease (n=28, 42.2%) were the most common conditions.
Conclusion: Patient characteristics at onset of insulin treatment showed family history of T2DM, high presence of cardiovascular risk factors and micro/macrovascular complications. Most of the patients were prescribed human basal insulin or premix human insulin, showing treatment pattern in routine clinical practice in Spain at that moment.
Prague, Czech Republic
24 - 28 Apr 2010
European Society of Endocrinology