Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2010) 22 P331 

Transient insulin resistance during the laparoscopic versus open cholecystectomy

Dusan Micic1, Snezana Polovina3, Jelena Micic2, Zlatibor Loncar1, Dragan Micic4 & Vladimir Djukic1

Author affiliations

Aim: The aim of our study was to investigate is surgical stress induce alterations in insulin sensitivity in the course of cholecystectomy performed in two differnt procedures: as a open surgery and as laparascopic operation.

Material and methods: The homeostasis assessment model (HOMA) was used to determine insulin sensitivity before and in the first, third and seventh day after the operation. Patients were divided int two groups: group A (open cholecystectomy; n=8; mean age 38.0±3.3; mean BMI 26.8938±1.5679) and group B (laparoscopic cholecystectomy; n=7; mean age 39.6±4.1; mean BMI 26.5867±1.8531).

Results: There were no diferences in HOMA index between group A and B before the operation (mean 2.4010±0.3230 vs 1.9798±0.6985; P>0.05) as well as for day 1 (2.5448±0.6044 vs 1.8370±0.5714; P>0.05) and day 7 (0.6494±0.4349 vs 0.7232±0.3898; P> 0.05). Group B had higher HOMA index at day 3 (7.5619±2.3360 vs 2.8016±0.7670; P<0.05).

Conclusion: There is transient increase in HOMA index after the operation in both procedures, compatible with deterioration in insulin sensitivity due to stress–response that is normalized a week after the operation.

This Issue/Conference

Article tools

My recent searches