ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2010) 22 P338 
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Vitamin D and glycaemic control

Ifigenia Kostoglou-Athanassiou1, Razvan Alexandros Badila1, Panagiotis Athanassiou2, Aikaterini Michou1, Aikaterini Chronaiou1, Dimitris Stefanopoulos1, Thomais Terzi1 & Areti Karfi1

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Introduction: Research results from different countries show that vitamin D deficiency is a modern reality, affecting even sunny countries. Vitamin D deficiency has been related to predisposition to the development of diabetes mellitus type 2 and it may affect the secretion and action of insulin.

Aim: The aim was to study the effect of vitamin D on glycaemic control in patients with diabetes mellitus type 2.

Materials and methods: The levels of HbA1c and 25(OH)vitaminD3 (25(OH)D3) were measured in 132 patients with diabetes mellitus type 2 (aged 37–80 years) and 61 control subjects aged 23–77 years.

Results: HbA1c levels were 7.24±0.17% (mean±S.E.M.) and 5.05±0.06% in diabetes mellitus type 2 patients and control subjects, respectively. Levels of 25(OH)D3 were 20.35±0.97 and 25.84±1.59 ng/ml in diabetes mellitus type 2 patients and control subjects, respectively. A reverse relationship was observed between the levels of HbA1c and 25(OH)D3 in diabetes mellitus type 2 patients (linear regression analysis, P<0.005) and in the control subjects (linear regression analysis, P=0.005). The reverse relationship between HbA1c and 25(OH)D3 persisted when the results of diabetes mellitus type 2 patients and the control subjects were pooled and analyzed together (linear regression analysis, P<0.001).

Conclusion: These results show that patients with diabetes mellitus type 2 had lower vitamin D3 levels than the control subjects and that patients with poorly controlled diabetes mellitus type 2 had lower vitamin D3 levels than the better controlled ones. Blood glucose values in both the diabetic and the control subjects appear to be inversely related to vitamin D3 levels. It appears that 25(OH)D3 affects glycaemic control in patients with diabetes mellitus 2.

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