Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2010) 22 P339 

Maternal obesity and gestational diabetes mellitus

Anargyros Kourtis, Athina Giomisi, Kali Makedou, Maria Mouzaki, Ioannis Kalogiannidis, Alexandros Traianos, Nikolaos Prapas & Theodoros Agorastos

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Objective: Numerous studies have reported an increased risk of gestational diabetes mellitus (GDM) among women who are overweight or obese compared with lean or normal-weight women. Obesity contributes to multiple health problems during pregnancy and predisposes a woman to develop GDM. Obesity is defined as a body mass index (BMI) of >30. Overweight is defined as a BMI of 25.0–29.9 and normal weight is defined as a BMI 20–24.9. The aim of the present study was to investigate BMI alterations throughout pregnancy in normal pregnancies and in those complicated by GDM.

Subjects and methods: We studied 211 women from the outpatient clinic of metabolic disorders in pregnancy. These women were ordered to perform the oral glucose tolerance test (OGTT) with 75 g of glucose, between 26th and 28th week of pregnancy. In 14 (6.64%) women, GDM (two or three values above normal) was diagnosed, in 28 (13.27%) impaired glucose tolerance (IGT) (only one abnormal glucose value) was the diagnosis and 169 (80.1%) women had normal OGTT results (controls). Weight, height and age of the women were analyzed and BMI (weight/height2) was calculated in the beginning of pregnancy (BMI-0), between 26th and 28th week of pregnancy (BMI-1) and between 32nd and 34th week (BMI-2).

Results: Mean BMI-0 values were significantly elevated in women who presented GDM in comparison to those with IGT or normal OGTT results (P<0.05). The increase in BMI values was analogous in all three groups of pregnant women, without statistically significant difference between BMI-0, BMI-1 and BMI-2 values of women of the same group.

Conclusion: Our findings confirm that high maternal weight is associated with a substantially higher risk of GDM.

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