Metastatic mammary carcinomas with neuroendocrine features- a case report
Andreea Brehar, Alexandra Bulgar & Constantin Dumitrache
Mammary carcinomas with endocrine differentiation are an uncommon subtype of breast carcinomas that are morphologically indistinguishable from low-grade endocrine neoplasm arising in other organs.
Neuroendocrine cells are present in mammary tissue. Neuroendocrine differentiation can be found in benign and malign lesions of various organs. Recent studies have reported the existence of neuroendocrine differentiation in breast carcinomas as being between 3% and 21%. Neuroendocrine differentiation detected in breast carcinomas shows morphological similarities to carcinomas of the gastrointestinal system and lung. However they are morphologically and clinically different from the classical carcinoid tumor of other systems. Hormone production of the tumor is rarely present.
We present a case of a forty-seven year old woman with mammary carcinomas ER+, PRG+, HER2-, without neuroendocrine receptor with multiple metastases who was operated and received chimiotherapies with completed remission. After two years she developed cervical ganglionar metastases and the biopsy with IHC indicated secondary determination of mammary carcinoma with neuroendocrine differentiation. She started chimiotherapy with immunotherapy and the evolution is better.