Introduction: Two patients admitted for evaluation of a hypercalcemia and hypothyroidism whose etiologic diagnosis showed itself unusual.
Case no. 1: A 45 years old man allowed for disorders of consciousness, vomitings and headaches, biology showed a hypercalcemia, a hypophosphoraemia, hyperPTH. The imaging revealed parathyroidal adenoma with a compressive prolactinema. Pet Scan-FDG showed a metabolic activity of the thymic cavity with a necrotic aspect, five pancreatic nodules and adrenal nodules without pheochromocytoma.
He has benefited from the resection of a parathyroidal adenoma from thymoma of P3 type invasive and hypophyseal adenomectomy. Search of MEN1 was positive.
Case no. 2: A 58 years old Mrs admitted for hypothyroidism post-radiation of a thymic carcinoma diagnosed 3 years earlier. Biology showed a hypercalcemia, a hypo phosphoraemia, hyperPTH in touch with parathyroidal adenoma. Imaging showed adrenal mass. Immunohistology ended has a pheochromocytoma. Besides, she presents a gastritis. The search of one MEN1 was negative.
Conclusion: These cases illustrate the interest of a fine analysis of the usual clinical and biological data as well as the contribution of the current techniques of biology and imaging for the etiologic and topographic.
Prague, Czech Republic
24 - 28 Apr 2010
European Society of Endocrinology