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Endocrine Abstracts (2010) 22 P461

ECE2010 Poster Presentations Female reproduction (44 abstracts)

Estrogen plus progestin treatment: effect of different progestin components on serum markers of apoptosis in healthy postmenopausal women

Maria Karaflou 1 , George Kaparos 2 , Demetrios Rizos 2 , Emanuel Logothetis 1 , Andreas Alexandrou 3 , Leon Aravantinos 1 , Maria Creatsa 1 , George Christodoulakos 1 , Irene Lambrinoudaki 1 & Evangelia Kouskouni 1

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1Second Department of Obstetrics and Gynecology, School of Medicine, Aretaieio Hospital, University of Athens, Athens, Greece; 2Hormonal and Biochemical Laboratory, School of Medicine, Aretaieio Hospital, University of Athens, Athens, Greece; 3First Department of Surgery, School of Medicine, Laiko Hospital, University of Athens, Athens, Greece.

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.

Design: Randomized, double-blinded study.

Patients: One hundred healthy postmenopausal women.

Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2/NETA) for 6 months.

Main outcome measures: Serum soluble Fas (sFas), soluble Fas Ligand (sFasL) and cytochrome-c (cyt-c) at baseline and at 6 months.

Results: Serum sFas and serum sFasL significantly decreased in both groups. Serum cyt-c in both groups was undetectable. sFas/sFasL ratios were reduced in both groups.

Conclusions: sFas/sFasL ratios decreased in both groups suggesting a decrease in apoptosis associated with the above pathway. cyt-c levels were undetectable, suggesting an absence of mitochondria-associated apoptosis.

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Endocrine Abstracts
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