Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2010) 22 P462

1Second Department of Obstetrics and Gynecology, School of Medicine, Aretaieio Hospital, Athens University, Athens, Greece; 2Hormonal and Biochemical Laboratory, School of Medicine, Aretaieio Hospital, Athens University, Athens, Greece; 3First Department of Surgery, School of Medicine, Laiko Hospital, Athens University, Athens, Greece.


Background/aim: The role of neutrophils and platelets in atherothrombotic disease is well established. The aim of our study was to investigate the effect of hormone therapy and tibolone on the soluble markers of neutrophil and platelet activation, ADAM-8 and CD40L respectively, in healthy postmenopausal women.

Subjects and methods: One hundred and six healthy postmenopausal women were randomly allocated to: estradiol plus drospirenone (E2/DSP), estradiol hemihydrate 1 mg plus norethisterone acetate (E2/NETA) 0.5 mg and tibolone 2.5 mg. Serum ADAM-8 and CD40L were measured at baseline and at 6 months.

Results: Baseline values of ADAM-8 and CD40L were similar between groups. No significant changes were observed between baseline values and values at 6 months.

Conclusions: No association has been revealed between estrogen plus progestin treatment or tibolone on serum ADAM-8 and CD40L levels in healthy postmenopausal women. Larger prospective studies are needed to further investigate the effect of low-dose hormone therapy or tibolone on serum markers of neutrophil and platelet activation.

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