Endocrine Abstracts (2010) 22 P470

Serum vaspin levels in women with polycystic ovaries and polycystic ovary syndrome

Erman Cakal1, Yusuf Ustun2, Yaprak Engin-Ustun2, Mesut Ozkaya3 & Metin Kilinc4

1Department of Endocrinology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey; 2Department of Obstetrics and Gynecology, Inonu University Medical Faculty, Malatya, Turkey; 3Department of Endocrinology, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey; 4Department of Biochemistry, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey.

Objective: Our aim was to evaluate C-reactive protein (CRP) and serum vaspin levels in women with polycystic ovary syndrome (PCOS) or polycystic ovaries (PCO).

Design: Twenty-four women with PCOS and 23 women with PCO constituted the study groups. The control group comprised 24 healthy women.

Methods: Homeostatic model assessment for insulin resistance (HOMA-IR), CRP and serum vaspin levels were measured. The receiver operating characteristic curve (ROC) of vaspin for prediction of women with increased diabetogenic risk was constructed.

Results: The three groups did not significantly differ in age and body mass index. HOMA-IR was significantly higher in the PCOS and PCO groups than in control group. Median CRP levels in the control, PCO, and PCOS groups were 0.66, 1.28, and 3.2 mg/l, respectively (P=0.0001). Women with PCOS had significantly higher serum vaspin levels than the healthy controls (3.52±1.38 vs 0.36±0.19 ng/ml, P=0.0001). Serum vaspin could differentiate between women with and without increased diabetogenic risk at a cut-off value of: 1.82 ng/ml with a sensitivity of 83.3% and a specificity of 66.1%.

Conclusion: The results of our study showed that the presence of the increased vaspin, CRP and higher HOMA-IR levels in women with PCOS and PCO could contribute to increased diabetogenic and atherogenic risk in these patients.

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