Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2010) 22 P470 

Serum vaspin levels in women with polycystic ovaries and polycystic ovary syndrome

Erman Cakal1, Yusuf Ustun2, Yaprak Engin-Ustun2, Mesut Ozkaya3 & Metin Kilinc4

Author affiliations

Objective: Our aim was to evaluate C-reactive protein (CRP) and serum vaspin levels in women with polycystic ovary syndrome (PCOS) or polycystic ovaries (PCO).

Design: Twenty-four women with PCOS and 23 women with PCO constituted the study groups. The control group comprised 24 healthy women.

Methods: Homeostatic model assessment for insulin resistance (HOMA-IR), CRP and serum vaspin levels were measured. The receiver operating characteristic curve (ROC) of vaspin for prediction of women with increased diabetogenic risk was constructed.

Results: The three groups did not significantly differ in age and body mass index. HOMA-IR was significantly higher in the PCOS and PCO groups than in control group. Median CRP levels in the control, PCO, and PCOS groups were 0.66, 1.28, and 3.2 mg/l, respectively (P=0.0001). Women with PCOS had significantly higher serum vaspin levels than the healthy controls (3.52±1.38 vs 0.36±0.19 ng/ml, P=0.0001). Serum vaspin could differentiate between women with and without increased diabetogenic risk at a cut-off value of: 1.82 ng/ml with a sensitivity of 83.3% and a specificity of 66.1%.

Conclusion: The results of our study showed that the presence of the increased vaspin, CRP and higher HOMA-IR levels in women with PCOS and PCO could contribute to increased diabetogenic and atherogenic risk in these patients.

This Issue/Conference

Article tools

My recent searches