Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2010) 22 P473 

Metabolic syndrome indices and Framingham risk scoring in women with polycystic ovary syndrome

Djuro Macut, Ivana Bozic, Bojana Popovic, Tamara Bogavac, Milan Petakov, Sanja Ognjanovic, Tatjana Isailovic & Svetozar Damjanovic

Author affiliations

Objectives: It is well known that polycystic ovary syndrome (PCOS) can promote metabolic syndrome (MetSy) and consequently cardiovascular diseases (CVD). In this study we compared indices of MetSy and 10-year cardiovascular risk (CVR10) based on Framingham risk scoring system (FRSS) in young obese PCOS women and healthy obese controls.

Methods: We studied 25 obese women with PCOS (mean age: 29.55±4.6 years, mean BMI: 31.8±4.4 kg/m2) diagnosed using Rotterdam 2003 Consensus criteria and 25 age and BMI matched obese controls. All women had waist circumference >80 cm. The following analyses were performed: total cholesterol, HDL, triglycerides, glucose, insulin, C-peptide, testosterone, SHBG, DHEAS and systolic blood pressure. Calculation of free androgen index (FAI) was performed and insulin resistance was defined by HOMA-IR. MetSy was defined by International Diabetes Federation criteria, and a CVR10 according to FRSS. Because subject age had major influence to final CVR10 estimation, we compared gathered points as well.

Results: In comparison to obese controls, obese PCOS women had statistically significant higher glucose (P<0.01), testosterone (P<0.001) concentrations, as well as higher FAI (P<0.001). SHBG concentration was lower in PCOS than in controls (P<0.01). There was no significant difference in other parameters, including HOMA-IR. Both groups had the same prevalence of MetSy (PCOS versus controls: 26 vs 22%, P>0.05). There was similar number of smokers in PCOS and control group (52 vs 44% respectively, P>0.05). CVR10 for PCOS women was 1.6% and for controls 1.4% (P>0.05). Framingham risk score points for PCOS were 7.8±5.0 and for controls 6.8±6.6 (P>0.05).

Conclusion: Young obese women with PCOS do not have greater 10-year risk for incident cardiovascular diseases in comparison to age and body mass index matched healthy women, based on Framingham risk score system. A different system for CVD prediction in this population of women is needed.

This Issue/Conference

Article tools

My recent searches