Endocrine Abstracts (2010) 22 P563

Influence of psychological variables on partially and fully recovering in patients with anorexia nervosa

Marina Djurovic, A Arsic, Sandra Pekic, Dragana Miljic, Mirjana Doknic, Milan Petakov, Marko Stojanovic & Vera Popovic


Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Belgrade, Serbia.


Introduction: Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. A product of complex interactions between psychological and clinical variables are important for the presence of the disease.

Aim: The aim of the study was to investigate the variables which might predict full reproductive recovery of patients with anorexia nervosa.

Material and methods: We studied closely matched cohorts of patients with partailly (n=10) and fully recovered (n=13) AN patients (DSM-IV criteria). They were matched for age (23.1±0.34 vs 25.1±1.2 years, P>0.05), for body weight (49.2±1.1 vs 52.8 ±1.5, P>0.05) and body mass index (BMI 18.3±0.4 vs 19.5±0.4 kg/m2, P>0.05). Samples for pooled serum leptin levels (RIA, Linco) and for LH and FSH (Irma, INEP) were measured. Depression was assessed by Beck Depression Inventory Second Edition (BEK-BD-II) and anxiety by Hamilton Anxiety Scale (HAMA).

Results: There was a significant negative correlation between body weight and the score of BEK (P=0.04), body weight and HAMA scale score of anxiety (P=0.03). Patients with higher anxiety scores had lower body weight at baseline. The degree of depression correlated significantly with presence of amenorrhoea (P=0.04).

Conslusion: In a subset of AN patients, although regained weight, amenorrhoea was found. It is reasonable to believe that pshychological factors are important for the presence of disease.

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