IN HYPOPHOSPHATASIA (HPP), DEFICIENT ALP can ruin bones, bodies, and lives. Alexion Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2010) 22 P574 

Frequency of neuroendocrinal disturbances in patients with different pituitary adenomas

Mukhlisa Shakirova & Yulduz Urmanova

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Study objective: To study the frequency of neuroendocrinal disturbances in patients with different pituitary adenomas.

Material and methods: Under our observation there were 53 patients with various pituitary adenomas, of them female – 31, male – 22, middle age of 41.5 years. According to the aetiology of the underlying disease patients were sorted out as follows: 39 patients had an inactive pituitary adenoma, 2 – craniofaringeoma, 3 – Cushing’s disease, 25 prolactinoma, 1 – astrocytoma, 1 – meningioma, 1 – germinoma.

All patients underwent a complex of examinations including basic clinical, biochemical, radio immune hormonal (GH, IGF1, prolactinum, LH, FSH, TSH, ACTH, hydrocortisone, etc.), ophthalmologic (eyeground, vision fields) and X-ray examination (CT, MRI of sella turcica), and also a questionnaire survey of GH deficiency (GHD) in adults (QoL). The control group consisted of 20 healthy subjects of corresponding age.

Results: According to our data, in the 53 patients the following neuroendocrinal disturbances were observed: secondary amenorrhea – in 13 (25%) patients, primary infertility – in 5 (10%), galactorrhea – in 1 (2.5%), secondary hypogonadism – in 6 (12.5%), secondary hypocorticoidism – in 6 (12.5%), functional hyperprolactinemia – in 6 (12.5%), diabetes insipidus – in 1 (2.5%), GH deficiency – in 39 (73.5%), hypopituitarism – in 12 (22.6%), panhypopituitarism – in 2 (3.7%), secondary hypothyrosis – in 6 (12.5%) patients. The prevailing majority of patients had visual disturbances: bitemporal hemianopsia – 41 (79.1%) patients, amaurosis unilateral – 4 (8.3%), 8 quadrant unilateral hemianopsia – (16.6%), concentric narrowing of visual fields – 22 (41.6%), partial atrophy of optic nerves – 15 (29.1%), paracentral absolute scotoma – 4 (8.3%) patients.

GHD in adults questionnaire (QoL) data analysis has shown that in our patients a reliable significant depression of a psycho-emotional status took place in 39 cases with GHD (73.5%).

Conclusions: i) The most frequent disturbance in patients with pituitary adenomas was the bitemporal hemianopsia – 41 (79.1%) and GHD – in 39 patients (73.5%). ii) A feature of clinical manifestations of GHD in adults is a significant depression of a psycho-emotional status of patients against the background of neuroendocrinal disturbances that is supported by the data of the special questionnaire (QoL) for adults with GHD in all 39 patients (73.5%).

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