Manifestation factors of the disease and complications rate in patients with acromegaly from Aral Sea regions of the Republic of Uzbekistan
Yulduz Urmanova, Nazira Salakhova, Liliya Murtazaeva, Khudoyar Askarov, Jenis Pirniyazov, Lola Romanova, Shukhrat Khodgaev & Maryam Rakhmetova
Aim of the research: To study manifestation factors of the disease in patients with acromegaly in patients from Aral sea regions of the Republic of Uzbekistan.
Patients and methods: Of the 43 patients with acromegaly assessed in Khorezm Region and Republic of Karakalpakstan (RKK) in 2009 22 were men (51.1%) and 21 women (48.8%).
Of the 17 acromegalic patients registered in RKK 4 male patients and 13 female patients. Mean age of men 40.7 years-old and women 41.3 years-old. Of the 13 female patients 2 women (15.3%) received a radiotherapy while other 15 patients (88.2%) receive medical treatment with Bromergon. Duration of the disease was from 1 to 25 years.
Of the 26 patients with acromegaly registered in Khorezm region 9 men and 17 women. Mean age of male patients 42.6 years-old and 42.1 years-old of female patients. Of the 26 female patients with acromegaly 2 women (7.7%) underwent transphenoidal surgery, whereas other 24 patients (92.3) receive medical treatment with Bromergon.
Results: Seventeen patients with acromegaly registered and followed-up in RKK. These patients developed complications such as secondary diabetes mellitus (DM) in 2 patients (11.8%), impaired glucose tolerance (IGT) in 1 case (5.9%), dyscirculation encephalopathy (DE) in 10 patients (58.8%), arterial hypertension (AH) in 9 patients (52.9%), acromegalic cardiac myopathy in 4 patients (23.5%), ischemic heart disease (IHD) in 2 patients (11.8%). Triggering factors were traumas in 2 patients (11.8%), stress in 2 patients (11.8%) while 13 patients (76.5%) had no any triggering issues.
Of the 26 patients with acromegaly registered in Khorezm region 9 men (34.6%) and 17 women (65.4%). These patients developed complications such as secondary diabetes mellitus (DM) in 11 patients (42.3%), IGT in 2 cases (7.7), DE in 16 patients (61.5%), AH in 12 patients (46.2%), IHD in 2 patients (7.7%), transitory brain blood flow failure in 16 patients (61.5%). Triggering factors were traumas in 2 patients (3.8%), stress in 1 patient (3.8%) while 24 patients (92.3%) had no any triggering issues.
Conclusions: i) Analysis of 43 patients with acromegaly in Aral Sea region showed the prevalence of manifestation factors such as traumas in 3 patients (6.9%) and stress in 3 cases (6.9%); ii) of the metabolic and vascular complications DE in 26 patients (60.4) prevailed, as well as AH in 12 patients (27.9%), transitory brain blood flow failure in 16 patients (37.2%) and secondary DM in 13 cases (30.2%).