Endocrine Abstracts

Aim of the research: To study manifestation factors of the disease in patients with acromegaly in patients from Aral sea regions of the Republic of Uzbekistan.

Patients and methods: Of the 43 patients with acromegaly assessed in Khorezm Region and Republic of Karakalpakstan (RKK) in 2009 22 were men (51.1%) and 21 women (48.8%).

Of the 17 acromegalic patients registered in RKK 4 male patients and 13 female patients. Mean age of men 40.7 years-old and women 41.3 years-old. Of the 13 female patients 2 women (15.3%) received a radiotherapy while other 15 patients (88.2%) receive medical treatment with Bromergon. Duration of the disease was from 1 to 25 years.

Of the 26 patients with acromegaly registered in Khorezm region 9 men and 17 women. Mean age of male patients 42.6 years-old and 42.1 years-old of female patients. Of the 26 female patients with acromegaly 2 women (7.7%) underwent transphenoidal surgery, whereas other 24 patients (92.3) receive medical treatment with Bromergon.

Results: Seventeen patients with acromegaly registered and followed-up in RKK. These patients developed complications such as secondary diabetes mellitus (DM) in 2 patients (11.8%), impaired glucose tolerance (IGT) in 1 case (5.9%), dyscirculation encephalopathy (DE) in 10 patients (58.8%), arterial hypertension (AH) in 9 patients (52.9%), acromegalic cardiac myopathy in 4 patients (23.5%), ischemic heart disease (IHD) in 2 patients (11.8%). Triggering factors were traumas in 2 patients (11.8%), stress in 2 patients (11.8%) while 13 patients (76.5%) had no any triggering issues.

Of the 26 patients with acromegaly registered in Khorezm region 9 men (34.6%) and 17 women (65.4%). These patients developed complications such as secondary diabetes mellitus (DM) in 11 patients (42.3%), IGT in 2 cases (7.7), DE in 16 patients (61.5%), AH in 12 patients (46.2%), IHD in 2 patients (7.7%), transitory brain blood flow failure in 16 patients (61.5%). Triggering factors were traumas in 2 patients (3.8%), stress in 1 patient (3.8%) while 24 patients (92.3%) had no any triggering issues.

Conclusions: i) Analysis of 43 patients with acromegaly in Aral Sea region showed the prevalence of manifestation factors such as traumas in 3 patients (6.9%) and stress in 3 cases (6.9%); ii) of the metabolic and vascular complications DE in 26 patients (60.4) prevailed, as well as AH in 12 patients (27.9%), transitory brain blood flow failure in 16 patients (37.2%) and secondary DM in 13 cases (30.2%).