Endocrine Abstracts (2010) 22 P680

Relationship between the breast cancer and abdominal obesity

Nermin Tuncbilek1, Sibel Guldiken2, Tulay Kilic Okman3, Atakan Sezer4, Semsi Altaner5, Asli Mentes1 & Huseyin Ozdemir1

1Department of Radiology, Faculty of Medicine, Trakya University, Edirne, Turkey; 2Department of Endocrinology, Faculty of Medicine, Trakya University, Edirne, Turkey; 3Department of Obstetrics and Gynecology, Faculty of Medicine, Trakya University, Edirne, Turkey; 4Department of General Surgery, Faculty of Medicine, Trakya University, Edirne, Turkey; 5Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Purpose: Numerous epidemiological studies have shown that obesity is a risk factor for postmenopausal breast cancer and relapse. We aim to investigate the relation between the upper abdominal obesity and breast cancer, by using ultrasonography (USG).

Material and methods: The study population consisted of 44 women in control group and 17 breast cancer patient in study group. In the whole study population fat tissue was measured with high resolution B-mode USG. The anthropometric measurements ((body mass index (BMI), waist/hip ratio (WHR) and waist circumference (WC)) were assessed in all study groups. The statistical analysis between with breast cancer and control group was assessed by Independent sample t-test.

Results: The mean BMI, total fat mass, and WC values were detected higher in breast cancer group with respect to control group (29.9; 28.9 kg; 94 cm; and 28; 24 kg; 88 cm respectively). The mean USG examination value of visceral fat tissue was measured 49.2 mm in breast cancer group, and 35.4 mm in control group. There was statistically significant difference between the group breast cancer and control group in visceral fat tissue, fat mass, and WC (P<0.05).

Discussion: This is the first clinical ultrasonography examination study investigating detection of the association between breast cancer and upper abdominal obesity. The results of our study correspond with the previous literature data concerning the relation of increased risk of breast cancer and general obesity. The data of the current study presents that general obesity and increase visceral fat tissue is a significant predictor of breast cancer, while subcutaneous and preperitoneal fat tissue are not related to increased risk.

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