Endocrine Abstracts (2010) 22 P684

Relation of PPAR[gamma] genetic polymorphism and testosterone levels in males with metabolic syndrome

Joanna Stankiewicz-Olczyk & Marek Bolanowski

1Copper Medical Center, Lubin, Poland; 2Medical University, Wroclaw, Poland.

Obesity and overweight are nowadays very important health problems. Metabolic syndrome increases the risk of diabetes mellitus and coronary heart disease. Patients suffering from metabolic syndrome, especially males, are at greater risk of acute cardiovascular episodes, like heart infarct or brain stroke, than patients without this, widely accepted atheromatosis’ risk farctor. The aim of the study was assessment of possible relations of PPARγ genetic polymorphism and selected hormones levels in males with metabolic syndrome. The study was carried out in a group of 402 professionally active males aged 30–60 years. They were studied PPARγ gene polymorphism, TSH, testosterone and adiponectin concentrations, and anthropometric measurements. We have shown no relation between occurrence of metabolic syndrome and PPARγ polymorphism. Subjects with Pro12Pro genotype had higher testosterone levels than those with Pro12Ala one. No such differences were observed when TSH and adiponectin concentrations were studied. Conclusions: Pro12Ala PPARγ genetic polymorphism does not determine the occurrence of metabolic syndrome in a studied group of profesionally active males. In males with metabolic syndrome, higher testosterone concentration coincides more often with Pro12Pro genotype than with Pro12Ala one.

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