Carotid intima media thickness increased similarly in subclinical hypothyroidism and clinical hypothyroidism
Elif Onder1, Yusuf Aydin1, Emel Acar2, Hakan Cinemre2, Seher Kir1, Adem Gungor2, Esra Yildizhan2 & Gokhan Celbek1
Introduction: Recent conducted studies show that clinical hypothyroidism (CH) has similar cardiovascular risk with subclinical hypothyroidism (SCH). Carotid intima media thickness (CIMT) that is an important marker of early atherosclerotic changes is an indicator of cardiovascular events. In our study, we evaluated CIMT in female patients, who have both CH and SCH, with similar age and demographic features.
Materials and methods: We recruited 38 healthy female and 81 female patients who admitted to endocrinology outpatient clinic of Duzce University School of Medicine, diagnosed as either CH (30) or SCH (51) and have not previously received treatment. Patients BMI (body mass index), systolic and diastolic blood pressure, triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol, vitamin B12, folate, homocysteine, high-sensitivity C-reactive protein (Hs CRP) and CIMT were measured.
Results: There was no statistically significant difference between groups in terms of age, BMI and lipid profiles (P>0.05). There was a statistically significant difference between groups in Hs CRP (P: 0.011) and homocysteine (P<0.001) and also there was a significant difference in mean CIMT between healthy control group and CH/SCH groups (P<0.001). In multiple linear regression analysis of patients with CH and SCH, the age was identified as the most important indicator of an increase in CIMT.
Discussion: Lack of difference between CH and SCH patients in terms of Hs CRP, homocysteine and CIMT shows that inflammation starts and CIMT increases in SCH period. Therefore, we think as, in order to primary prevention of the cardiovascular diseases in patients with SCH regardless of the TSH levels, treatment of patients is clinically important.