Have the hypothyroid patients really had euthyroid' quality of life after the euthyroid state is established with levothyroxine-substitution?
Zoran Gluvic1, Jelena Tica1, Vesna Popovic-Radinovic1, Marina Vujovic1, Zorica Rasic-Milutinovic1, Milena Lackovic1, Esma Isenovic2 & Nevena Paunovic3
Introduction: Subclinical and clinical primary hypothyroidism potentially makes a negative influence on the patients quality of life. Present study examined the level of hypothyroid symptoms and signs expression as well patients quality of life before levothyroxine and after substitutionally-induced laboratory euthyroidism.
Material and methods: Prospective casecontrol study consisted of 75 female patients divided into three groups based on blood levels of TSH and thyroid hormones before levothyroxine substitution began. Examinees autonomously fulfilled two structured interviews, TSQ and GHQ-12. Obtained answers were numerically transformed into ranks and presented through two scores, standard and modified. Data were analyzed by usage of SPSS for Windows 12.0.
Results and discussion: A mean follow-up period of study enrolled patients until levothyroxine-induced laboratory euthyroidism was 6 months, with no significant difference among groups (Z=−1.708, P>0.05). The mean standard and modified TSQ and GHQ-12 scores were 13 and 10 respectively and statistically significant difference was not registered between groups (; ; ; ; df=2; P>0.05). Obtained scores correlated with the individual patients satisfaction of levothyroxine therapy (ρTSQstandard=0.309; ρTSQmodified=0.323; ρGHQstandard=0.405; ρGHQmodified=0.399; P<0.01).
Conclusion: Given scores classified the study patients in the group with no mental distress. That pointed out levothyroxine substitution as adequate and satisfied quality of life of treated patients.