Endocrine Abstracts (2010) 22 P799

Therapeutic effect of sesame oil on monosodium urate monohydrate crystal-induced acute inflammation in rat air pouches

Te-Jung Hsu, Pey-Yi Chu & Ming-Yie Liu


National Cheng Kung University Medical College, Tainan, Taiwan, ROC.


Hyperuricemia, results from the disorder of purine metabolism or endocrine system, leads to an inflammatory arthritis and gout. Sesame oil has been reported to have a potent anti-inflammatory effect in various animal models. The aim of the present study is to examine the therapeutic effect of sesame oil on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in air pouch in unanaesthetised Sprague–Dawley rats. Air pouch, a commonly used model for gouty arthritis, was established in rats by injecting 10 and 3 ml of sterilized air into subcutaneous tissue of the back at day -6 and day -3, respectively. At day 0, inflammation in air pouch was induced by injecting MSU crystal (5 mg/rat, suspended in sterilized phosphate buffered saline, pH 7.4), while sesame oil (0, 1, 2, or 4 ml/kg, orally) was given 6 h after MSU injection. Total cell counts, nitrite, and inflammatory cytokines levels in lavage and tissue from pouch were determined 6 h after sesame oil administration. MSU crystal increased the total cell counts, nitrite, interleukin (IL)-1β, and IL-6 levels in lavage compared with normal group. Sesame oil significantly decreased all the parameters in a dose-dependent manner compared with MSU alone group. In addition, sesame oil significantly decreased tumour necrosis factor-α, IL-1β, IL-6 levels in pouch tissue compared with MSU alone group. In conclusion, sesame oil showed a potent therapeutic effect against MSU-induced inflammation in rats. Further, sesame oil may have the potential in treating patients with gouty arthritis in the future.

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