Effects of L-thyroxine treatment on resistin and high-sensitive CRP levels in patients with subclinical hypothyroidism
Duygu Yazgan Aksoy, Ayla Harmanci, Nese Cinar, Bulent Okan Yildiz, Aydan Usman & Miyase Bayraktar
Background: Subclinical hypothyroidism (SH) is an endocrine disorder defined by increased thyrotropin (TSH) levels associated with normal free thyroxine (fT4) and free triiodothyronine (fT3). Resistin is secreted from the adipose tissue and is reported to be associated with insulin resistance and/or inflammation. High-sensitive CRP (hs-CRP) is a reliable marker of inflammation. Data related to levels of resistin and hS-CRP in SH is limited.
Aim: We aimed to determine the levels of resistin and hs-CRP in women with SH and potential effects of L-thyroxine therapy on those levels.
Materials and methods: Thirty-four women with SH were included. All patients received L-thyroxine for 6 months and reevaluated. Resistin and hs-CRP levels were from studied frozen samples after the completion of the study.
Results: All patients reached euthyroid status after therapy. TSH decreased and fT4 increased (P<0.001). Resistin and hs-CRP levels did not change significantly after 6 months of L-thyroxine therapy.
Conclusions: Our results suggest that achievement of euthyroid status by replacement therapy did not change resistin or hs-CRP levels in women with SH. SH is known to alter metabolic functions. Previous studies reported different changes in adipokines according to thyroid status. Further studies are needed to clarify the interaction between thyroid function status, metabolic parameters, inflammatory markers and adipokines.