Endocrine Abstracts

Many studies show insufficient and inadequate vitamin D and calcium levels in postmenopausal women with osteoporosis, thus emphasising the need for supplementation therapy.

Aim of the study: To determine vitamin D (25(OH)D) and ionised calcium levels in women treated for postmenopausal osteoporosis at our Clinic in the course of year 2009.

Materials and methods: We prospectively followed up 116 women at the age of 59.38±5.55 (minimal age 48, maximum age 69). The diagnosis of osteoporosis was established by dual X-ray absorptiometry (DXA) of spine and hip. Levels of 25(OH)D and ionised calcium were determined by standard laboratory measurements.

Results: Mean spine T score value was −3.07±0.47 (minimal – 4.5, maximal – 2.6). Average 25(OH)D level was 45.12±16.68 nmol/l (minimal 10 nmol/l, maximal 81 nmol/l). Fifteen women (12.93%) had levels of <25 nmol/l (group I). In the group II there were 57 women (49.14%) with the levels between 25 and 50 nmol/l (group II). Group III consisted of 39 women (33.62%) with 25(OH)D levels between 51 and 75 nmol/l. Only five women (4.31%) had 25(OH)D levels over 75 nmol/l and they comprised group IV. Average ionised calcium level was 0.97±0.07 nmol/l (minimal 0.90 mmol/l, maximal 1.2 mmol/l). In our groups I, II, III and IV ionised calcium levels were 0.97±0.05, 0.98±0.07, 0.97±0.05 and 1.06±0.08 mmol/l respectively.

Conclusion: Our results show inadequate vitamin D and calcium levels in about 50% women with postmenopausal osteoporosis. Measurements of vitamin D and calcium together with their supplementation in necessary in prevention and treatment of postmenopausal osteoporosis.