Rapid androgen action in epithelial and stromal cells
Gabriella Castoria, Antimo Migliaccio, Pia Giovannelli, Tiziana Giraldi & Ferdinando Auricchio
Androgen stimulation triggers rapid activation of signaling pathways in target cells. The initial event is a rapid interaction of classical androgen receptor (AR) with Src. Activation of these pathways fosters cell cycle, prevents apoptosis and leads to cytoskeleton changes in reproductive as well as non-reproductive cells. The role of Src activation in the androgen proliferative action has been recently corroborated by findings showing that specific interference in Src/AR association by synthetic peptide impairs prostate cancer cell growth in mouse model of tumorigenesis. Furthermore, androgen activation of signalling pathways controls cell migration and wound healing in fibroblasts. These findings may account for the role of AR in promoting tissue remodelling as well as cell spreading and metastasis. Examples of the functions of signalling pathways in androgen action will be here presented.