Functional status of pituitarygonads axis in males with obesity
Y. Urmanova & I. Nabieva
Aim: to study functional status of pituitarygonads (PG) axis in males with obesity.
Materials and methods: We evaluated 15 males with obesity without other associated pathology. Mean age of patients was 28.3 years old. Control group constituted by 20 healthy men with different age.
All patients underwent clinical and biochemical evaluations including endocrine check, lipids profile, hormonal profile (LH, FSH, prolactin, sex steroid binding globulin, free testosterone), genitalia ultrasonography, height, body mass, waist circumference (WC), hip circumference (HC), waist-hip ratio, questioning and other studies.
Results: Hormonal profile showed normogonadotrphemia in nine patients (60%) (mean LH ranged 8.7±1, 2 mIU/l, FSH 6.4±1.5 mIU/l) and significantly low free testosterone levels (mean 5.6±0.3 ng/ml). Most of the patients had central obesity with BMI>35 kg/m2. WC was in normal range 104.3±7, 4 cm, HC=85, 6±5.3 cm, whereas waist-hip ratio >1, 22. Blood tests showed dyslipidemia in all patients (100%).
Conclusion: i) Most fertile men with obesity (60%) have normogonadotrophemia with partial decrease of free testosterone in all patients. ii) To discover the pathogenesis of PG axis disorders in men with obesity further researches are needed.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.