Endocrine Abstracts (2012) 29 P1214

Circulating oxidized LDL in patients with visceral obesity

A. Giestas, I. Palma, J. Oliveira, M. Ferreira & H. Ramos

Hospital Santo António, Centro Hospitalar do Porto, Oporto, Portugal.

Background: Visceral obesity has been associated with systemic oxidative stress, measured by oxidized LDL (oxLDL).

Aim: Investigate circulating oxLDL levels in patients with visceral obesity, and its relationship with metabolic abnormalities found in visceral obesity.

Methods: We evaluated blood pressure (BP), waist circumference (WC), fasting glucose, total cholesterol, LDL, HDL, triglycerides, ApoA1, ApoB, ApoCIII, Lp(a) and oxLDL in 100 asymptomatic non-smoking patients (56 men/44 women) aged 50–60 years, without cardiovascular disease.

Subjects were grouped as it follows: i) WC<102 cm in men and WC<88 cm in women; ii) WC≥102 cm in men and WC≥88 cm in women. Data processed in SPSS 16.0.

Results: Subjects with increased WC had higher systolic BP (women: 135+/−24 vs 146+/−27 mmHg, P<0.05; men: 134+/−22 vs 145+/−25 mmHg, P<0.05), higher levels of triglycerides (women: 129.5+/−54.0 vs 172.9+/−13.0 mg/dl, P<0.05; men: 132.2+/−18.0 vs 183.6+/−76.0 mg/dl, P<0.01) and ApoCIII (women: 8.8+/−4.3 vs 12.3+/−9.9 mmHg, P<0.01; men: 9.4+/−5.3 vs 14.4+/−7.4 mmHg, P<0.01), and lower HDL (women: 56.8+ /−11.8 vs 47.3+/−13.4 mg/dl, P<0.05; men: 44.5+/−11.1 vs 36.8+/ −10.4 mg/dl, P<0.05) and ApoA1 (women: 170.0+/−22.6 vs 152.6+/ −27.6 mg/dl, P<0.05; men: 144.6+/−22.3 vs 133.2+/−24.2 mg/dl, P<0.05). There was no significant difference (P>0.05) between the groups in fasting glucose, LDL, ApoB and Lp(a) levels; however, those with increased WC had higher levels of oxLDL (women: 59.8+/−14.7 vs 67.8+/−14.8 mg/dl, P<0.05; men: 61.3+/−21.1 vs 69.0+/−19.5 mg/dl, P<0.05).

OxLDL was positively correlated with WC (r=0.86, P<0.01), systolic BP (r=0.27, P<0.05), plasma triglyceride (r=0.29, P<0.05), ApoCIII (r=0.38, P<0.05), LDL (r=0.51, P<0.01) and ApoB (r=0.54, P<0.01); and negatively correlated with HDL (r=−0.26, P<0.01) and ApoA1 (r=−0.20, P<0.01).

Conclusion: The study showed that high WC was strongly associated with high levels of oxLDL.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.


Article tools

My recent searches

No recent searches.

My recently viewed abstracts