Hyperandrogenism and PCOS in adolescent girls with type 1 diabetes treated with intensive and continous insulin therapy
A. Zachurzok-Buczynska, G. Deja, A. Gawlik, A. Drosdzol-Cop & E. Malecka-Tendera
Women with T1DM experience high prevalence of hyperandrogenic disorders. Study aim was to examine whether they are present at adolescents and related to metabolic control and type of insulin therapy. Clinical characteristics, hormonal profile and ovarian volume were studied in 49 adolescent girls with T1DM. PCOS criteria were fulfilled in 11 (22.5%). Although girls with poor metabolic control had higher T (P=0.02) and 17-OH progesterone (P=0.03), frequency of PCOS did not correlate with T1DM duration and mean HbA1c and was independent of the type of insulin therapy. Girls with T1DM and PCOS were compared to 23 non-diabetic peers with PCOS (Table 1) and were found to have shorter cycle and lower ovarian volume and hirsutism score. This may be due to higher SHBG and lower FAI.
Conclusions: Although, irrespective of the type of insulin therapy, more than 20% of adolescents with T1DM experience PCOS, they show milder clinical and ultrasonographic symptoms of hyperandrogenism than their non-diabetic peer with PCOS.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
|T1DM+PCOS girls (n=11)||Control PCOS girls (n=23)||P|
|Chronological age (years)||16.5 (15.717.1) ||16.8 (15.517.3) ||NS|
|Gynecological age (months)||37.7±13.9 ||45.4±16.1 ||NS |
|Cycle duration (days)||31.0 (27.036.0) ||64.0 (35.2104) ||0.004 |
|Hirsutism score ||2.0 (1.05.0) ||11.0 (3.013.0) ||0.004 |
|Volume of the right ovary (ml) ||5.4±1.6 ||7.3±2.2 ||0.03 |
|Volume of the left ovary (ml)||4.2±1.8 ||7.1±3.2 ||0.01 |
|Testosterone (nmol/l)||1.8±0.9 ||2.0±1.0 ||NS |
|Androstenedione (nmol/l)||10.5±4.9 ||10.1±4.5 ||NS |
|DHEAS (μmol/l) ||5.4±2.0 ||7.1±2.4 ||0.05 |
|17OH progesterone (nmol/l)||4.2 (2.75.5) ||4.9 (3.66.7) ||NS|
|SHBG (nmol/l)||43.8±16.6 ||24.7±12.9 ||0.007 |
|FAI||3.0 (2.64.3) ||8.5 (6.510.8) ||0.001 |